Green Tea Polyphenols Protect against Acetaminophen-Induced Liver Injury by Regulating the Drug Metabolizing Enzymes and Transporters

Figure 2

Protective effect of GTP against APAP-induced hepatotoxicity in mice. Different doses (37.5 mg/kg, 75 mg/kg, or 150 mg/kg) of GTP were orally given to mice 4 h after a single dose of APAP (400 mg/kg) administration and continuously given every 8 h afterward. (a) Survival rate was monitored within 52 h after APAP overdose (n = 10). Additionally, mice were sacrificed at 4, 12, 20, or 48 h after the first dose of GTP. Serum and liver samples were harvested and processed as indicated in Materials and Methods. (b) Histopathological analysis of mouse liver samples following H&E staining. (c) Serum ALT activity, (d) serum AST activity, and (e) total liver GSH levels from mice in each group (n = 10). Results are presented as mean ± SEM (n = 10). versus the control group. versus the APAP group.

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