Research Article
Toxicity and Its Mechanism Study of Arecae semen Aqueous Extract in Wistar Rats by UPLC-HDMS-Based Serum Metabolomics
Table 3
The identification of potential biomarkers and their changes in rats induced by ASAE.
| | HMDB ID | Metabolites | Formula | tR (min) | Exact mass (m/z) | Determined (m/z) | Calculated (m/z) | Error (ppm) | Ion from | Related pathways | Trends/(mg/kg/d) | | 1500 | 4500 |
| | HMDB0000220 | Palmitic acid | C16H32O2 | 17.34 | 256.4241 | 255.2332 | 255.2324 | 3.1 | [M − H]− | Fatty acid metabolism | | ↑ | | HMDB0000673 | Linoleic acid | C18H32O2 | 15.30 | 280.4455 | 279.2322 | 279.2324 | −0.9 | [M − H]− | Linoleic acid metabolism | | | | HMDB0001043 | Arachidonic acid | C20H32O2 | 16.28 | 304.4669 | 303.2324 | 303.2324 | 0 | [M − H]− | Arachidonic acid metabolism | ↓ | | | HMDB0003229 | Palmitoleic acid | C16H30O2 | 14.43 | 254.4082 | 253.2168 | 253.2167 | 0.4 | [M − H]− | Fatty acid metabolism | | ↓ | | HMDB0000827 | Stearic acid | C18H36O2 | 9.14 | 284.4772 | 283.2635 | 283.2637 | −0.7 | [M − H]− | Fatty acid metabolism | | | | HMDB0010382 | LysoPC (16 : 0) | C24H50NO7P | 19.42 | 495.6301 | 494.3231 | 494.3252 | −4.3 | [M − H]− | Glycerophospholipid metabolism | ↑ | | | HMDB0007853 | LysoPA (16 : 0/0 : 0) | C19H39O7P | 20.00 | 410.4825 | 409.2359 | 409.2361 | −0.5 | [M − H]− | Glycerolipid metabolism | | — | | HMDB0000289 | Uric acid | C5H4N4O3 | 1.35 | 168.1103 | 167.0205 | 167.0211 | −3.6 | [M − H]− | Purine metabolism | — | ↑ | | HMDB0000619 | Cholic acid | C24H40O5 | 13.62 | 408.5714 | 407.2801 | 407.2803 | −0.5 | [M − H]− | Primary bile acid biosynthesis | — | | | HMDB0010381 | LysoPC (15 : 0) | C23H48NO7P | 18.38 | 481.6035 | 480.3084 | 480.3096 | −2.5 | [M − H]− | Glycerophospholipid metabolism | — | ↑ | | HMDB0011482 | LysoPE (0 : 0/20 : 1) | C25H50NO7P | 18.82 | 507.6408 | 506.3224 | 506.3252 | −5.5 | [M − H]− | Glycerophospholipid metabolism | — | ↑ | | HMDB0011481 | LysoPE (0 : 0/20 : 0) | C25H52NO7P | 20.54 | 509.6566 | 508.3387 | 508.3409 | −4.3 | [M − H]− | Glycerophospholipid metabolism | — | ↑ | | HMDB0002815 | LysoPC (18 : 1) | C26H52NO7P | 12.68 | 521.6673 | 522.3534 | 522.3559 | −4.8 | [M + H]+ | Glycerophospholipid metabolism | ↑ | | | HMDB0010386 | LysoPC (18 : 2) | C26H50NO7P | 11.36 | 519.6515 | 520.3380 | 520.3403 | −4.2 | [M + H]+ | Glycerophospholipid metabolism | ↑ | | | HMDB0010397 | LysoPC (20 : 5) | C28H48NO7P | 11.33 | 541.6570 | 542.3215 | 542.3246 | −5.7 | [M + H]+ | Glycerophospholipid metabolism | ↑ | | | HMDB0010404 | LysoPC (22 : 6) | C30H50NO7P | 11.32 | 567.6943 | 568.3373 | 568.3403 | −5.3 | [M + H]+ | Glycerophospholipid metabolism | ↑ | |
|
|
↑: upregulation compared with control group, ↓: downregulation compared with control group. , , . |
