Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Gegen Qinlian Decoction for Rotavirus Enteritis

Table 1

The active ingredients of GGQLD in TCMSP database (their targets intersected with enteritis genes).

Herbs	Compound name	OB	DL	PubChem ID
Pueraria lobate	Formononetin	69.67	0.21	5280378
	3′-Methoxydaidzein	48.57	0.24	5319422
	Daidzein-4,7-diglucoside	47.27	0.67	171292
Scutellaria baicalensis	Acacetin	34.97	0.24	5280442
	Wogonin	30.68	0.23	5281703
	(2R)-7-Hydroxy-5-methoxy-2-phenyl-2,3-dihydrochromen-4-one	55.23	0.2	821279
	Baicalein	33.52	0.21	5281605
	5,8,2′-Trihydroxy-7-methoxyflavone	37.01	0.27	156992
	5,7,3′,6′-Tetrahydroxy-6,8,2′-trimethoxyflavone	33.82	0.45	44258628
	Carthamidin	41.15	0.24	188308
	2,6,2′,4′-Tetrahydroxy-6′-methoxychalcone	69.04	0.22	78385588
	Dihydrobaicalin_qt	40.04	0.21	14135323
	Eriodyctiol	41.35	0.24	373261
	Salvigenin	49.07	0.33	161271
	5,2′,6′-Trihydroxy-7,8-dimethoxyflavone	45.05	0.33	5322059
	5,7,2′,6′-Tetrahydroxyflavone	37.01	0.24	5321865
	Dihydrooroxylin A	38.72	0.23	177032
	Skullcapflavone II	69.51	0.44	124211
	Oroxylin A	41.37	0.23	5320315
	Panicolin	76.26	0.29	5320399
	5,7,4′-Trihydroxy-8-methoxyflavone	36.56	0.27	5322078
	NEOBAICALEIN	104.34	0.44	124211
	2β-Phenyl-2,3-dihydro-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one	66.06	0.23	25721350
	β-Sitosterol	36.91	0.75	222284
	3-Epi-β-sitosterol	36.91	0.75	12303645
	Norwogonin	39.4	0.21	5281674
	5,2′-Dihydroxy-6,7,8-trimethoxyflavone	31.71	0.35	159029
	Ent-Epicatechin	48.96	0.24	182232
	Stigmasterol	43.83	0.76	5280794
	Coptisine	30.67	0.86	72322
	Bis[(2S)-2-ethylhexyl]benzene-1,2-dicarboxylate	43.59	0.35	7057920
	Supraene	33.55	0.42	638072
	Diop	43.59	0.39	33934
	Epiberberine	43.09	0.78	160876
	Moslosooflavone	44.09	0.25	188316
	11,13-Eicosadienoic acid, methyl ester	39.28	0.23	5365674
	5,7,4′-Trihydroxy-6-methoxyflavanone	36.63	0.27	5322074
	5,7,4′-Trihydroxy-8-methoxyflavanone	74.24	0.26	42608119
	Rivularin	37.94	0.37	13889022
Coptis chinensis	Berberine	36.86	0.78	2353
	Obacunone	43.29	0.77	119041
	Berberrubine	35.74	0.73	72703
	(R)-Canadine	55.37	0.77	443422
	Berlambine	36.68	0.82	11066
	AC1O7GAS	104.95	0.78	6604198
	Magnograndiolide	63.71	0.19	5319198
	Palmidin A	35.36	0.65	5320384
	Palmatine	64.6	0.65	19009
	Quercetin	46.43	0.28	5280343
	Worenine	45.83	0.87	20055073
	Moupinamide	86.71	0.26	5280537
Glycyrrhiza uralensis	Inermine	75.18	0.54	91510
	DFV	32.76	0.18	114829
	Mairin	55.38	0.78	64971
	Glycyrol	90.78	0.67	5320083
	Jaranol	50.83	0.29	5318869
	Medicarpin	49.22	0.34	336327
	Isorhamnetin	49.6	0.31	5281654
	3-Epi-β-sitosterol	36.91	0.75	12303645
	Lupiwighteone	51.64	0.37	5317480
	7-Methoxy-2-methyl isoflavone	42.56	0.2	911486
	Formononetin	69.67	0.21	5280378
	Calycosin	47.75	0.24	5280448
	Kaempferol	41.88	0.24	5280863
	Naringenin	59.29	0.21	932
	Shinflavanone	31.79	0.72	197678
	Glyasperin B	65.22	0.44	480784
	Glyasperin F	75.84	0.54	392442
	Glyasperin C	45.56	0.4	480859
	Isotrifoliol	31.94	0.42	5318679
	(E)-1-(2,4-Dihydroxyphenyl)-3-(2,2-dimethylchromen-6-yl)prop-2-en-1-one	39.62	0.35	10881804
	Kanzonol W	50.48	0.52	15380912
	(2S)-6-(2,4-Dihydroxyphenyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-7-one	60.25	0.63	637112
	Semilicoisoflavone B	48.78	0.55	5481948
	Glepidotin A	44.72	0.35	5281619
	Glepidotin B	64.46	0.34	442411
	Phaseolinisoflavan	32.01	0.45	4484952
	Glypallichalcone	61.6	0.19	5317768
	8-(6-Hydroxy-2-benzofuranyl)-2,2-dimethyl-5-chromenol	58.44	0.38	10542808
	Licochalcone B	76.76	0.19	5318999
	Licochalcone G	49.25	0.32	49856081
	Licoarylcoumarin	59.62	0.43	10090416
	Licoricone	63.58	0.47	5319013
	Gancaonin A	51.08	0.4	5317478
	Gancaonin B	48.79	0.45	5317479
	Licorice glycoside E	32.89	0.27	42607811
	Gancaonin L	66.37	0.41	14604077
	Gancaonin M	30.49	0.41	14604078
	Gancaonin O	44.15	0.41	14604081
	Glycyrin	52.61	0.47	480787
	Licocoumarone	33.21	0.36	503731
	Licoisoflavone	41.61	0.42	5281789
	Licoisoflavone B	38.93	0.55	5481234
	Licoisoflavanone	52.47	0.54	392443
	Shinpterocarpin	80.3	0.73	10336244
	(E)-3-[3,4-Dihydroxy-5-(3-methylbut-2-enyl)phenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one	46.27	0.31	11267805
	Liquiritin	65.69	0.74	503737
	Licopyranocoumarin	80.36	0.65	122851
	3,22-Dihydroxy-11-oxo-delta(12)-oleanene-27-alpha-methoxycarbonyl-29-oic acid	34.32	0.55	195396
	Glyzaglabrin	61.07	0.35	5317777
	Glabridin	53.25	0.47	124052
	Glabranin	52.9	0.31	124049
	Glabrene	46.27	0.44	480774
	Glabrone	52.51	0.5	5317652
	Hedysarimcoumestan B	48.14	0.43	11558452
	3,5-Dihydroxy-13,14-dimethoxy-8,17-dioxatetracyclo[8.7.0.0(2),.0(1) (1),(1)]hepta-deca-1(10),2,4,6,11,13,15-hepta-en-9-one	62.9	0.53	1160239
	Eurycarpin A	43.28	0.37	5317300
	Glycyroside	37.25	0.79	44257223
	(-)-Medicocarpin	40.99	0.95	23724664
	Sigmoidin-B	34.88	0.41	73205
	(2R)-7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one	71.12	0.18	928837
	Isobavachin	36.57	0.32	193679
	Isoglycyrol	44.7	0.84	124050
	Isolicoflavonol	45.17	0.42	5318585
	Isoformononetin	38.37	0.21	3764
1-Methoxyphaseollidin	69.98	0.64	480873
Quercetin der	46.45	0.33	52761906
3′-Hydroxy-4′-O-methylglabridin	43.71	0.57	15228662
Licochalcone A	40.79	0.29	5318998
3′-Methoxyglabridin	46.16	0.57	15228663
4′-Methoxyglabridin	36.21	0.52	9927807
Icos-5-enoic acid	30.7	0.2	3349565
Kanzonol F	32.47	0.89	101666840
6-Prenylated eriodictyol	39.22	0.41	13845972
7,2′,4′-Trihydroxy-5-methoxy-3-arylcoumarin	83.71	0.27	25015742
7-Acetoxy-2-methylisoflavone	38.92	0.26	268208
(2S)-3′,4′,5,7-Tetrahydroxy-8-prenylflavanone	53.79	0.4	13845973
Gadelaidic acid	30.7	0.2	5460988
Vestitol	74.66	0.21	92503
Gancaonin G	60.44	0.39	480780
Gancaonin H	50.1	0.78	5481949
Licoagrocarpin	58.81	0.58	15840593
Glyasperin M	72.67	0.59	101664572
Glycyrrhiza flavonol A	41.28	0.6	5317765
Licoagroisoflavone	57.28	0.49	636883
18-α-Hydroxyglycyrrhetic acid	41.16	0.71	101280181
Odoratin	49.95	0.3	13965473
Phaseol	78.77	0.58	44257530
Xambioona	54.85	0.87	14769500
Dehydroglyasperin c	53.82	0.37	480775
Quercetin	46.43	0.28	5280343