Fortified S-Allyl L-Cysteine: Animal Safety, Effect on Retinal Ischemia, and Role of Wnt in the Underlying Therapeutic Mechanism
Fluorogold retrograde RGC immunolabeling. The microscopic images of RGC (as indicated by arrowheads) density of the following groups (n = 4), namely, normal (a), Vehicle + I/R (b), SAC 0.0018 mg + I/R (c), I/R + SAC 0.0018 mg, and (d) each bar represents the mean ± SEM of the density of RGCs (e). () represents significant difference of Control vs. Vehicle + I/R, whereas †††/†† (/) indicates significant differences between Vehicle + I/R vs. SAC 0.0018 mg + I/R, or I/R + SAC 0.0018 mg. Scale bar = 50 μm. SAC, S-allyl L-cysteine; RGC, retinal ganglion cell; I/R, ischemic plus reperfusion.
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