Evidence-Based Complementary and Alternative Medicine

Research Article

Efficacy and Safety of Wenxin Granules and Propafenone in Treatment of Atrial Premature Beats: A Systematic Review and Meta-Analysis

Table 5

The adverse reactions of Wenxin granules and propafenone.


Adverse reactions	Study ID	Treatment group		Control group		Interventions	OR	95%CI
Adverse reactions	Study ID	Events	Total	Events	Total	Interventions	OR	95%CI

Sinus bradycardia	Shao MF2012	1	32	2	30	Wenxin granules and propafenone vs propafenone	0.45	[0.04,5.26]
	Wang HP2012	0	60	3	60	Wenxin granules and propafenone vs propafenone	0.14	[0.01,2.69]
	Zhao S2013	0	70	6	70	Wenxin granules and propafenone vs propafenone	0.07	[0.00,1.27]
	I² = 0% ()						0.15	[0.03,0.70]

Atrioventricular block	Wang HP2012	0	60	2	60	Wenxin granules and propafenone vs propafenone	0.19	[0.01,4.11]
	Zhao S2013	0	70	3	70	Wenxin granules and propafenone vs propafenone	0.14	[0.01,2.70]
	I² = 0% ()						0.16	[0.02,1.35]

Dizziness	Shao MF2012	2	32	2	30	Wenxin granules and propafenone vs propafenone	0.93	[0.12,7.08]
	Fan YN2018	1	30	1	32	Wenxin granules and propafenone vs propafenone	1.07	[0.06,17.89]
	Wang HP2012	3	60	0	60	Wenxin granules and propafenone vs propafenone	7.37	[0.37,145.75]
	Zhao S2013	4	70	0	70	Wenxin granules and propafenone vs propafenone	9.54	[0.50,180.64]
	I² = 0% ()						1.64	[0.60,4.45]
	Li ZM2010	2	77	0	51	Wenxin granules vs propafenone	3.41	[0.16,72.52]
	Meng FH2013	1	59	1	59	Wenxin granules vs propafenone	1.00	[0.06,16.37]
	I² = 0% ()						1.90	[0.27,13.50]

Dry mouth	Shao MF2012	2	32	0	30	Wenxin granules and propafenone vs propafenone	5.00	[0.23,108.53]
	Wang HP2012	1	60	0	60	Wenxin granules and propafenone vs propafenone	3.05	[0.12,76.39]
	Zhao S2013	2	70	0	70	Wenxin granules and propafenone vs propafenone	5.15	[0.24,109.15]
	I² = 0% ()						4.39	[0.73,26.32]
	Li ZM2010	2	77	0	51	Wenxin granules vs propafenone	3.41	[0.16,72.52]
	Meng FH2013	0	59	2	59	Wenxin granules vs propafenone	0.19	[0.01,4.11]
	I² = 41% ()						1.19	[0.19,7.63]

Gastrointestinal symptoms	Shao MF2012	2	32	0	30	Wenxin granules and propafenone vs propafenone	5.00	[0.23,108.53]
	Fan YN2018	1	30	1	32	Wenxin granules and propafenone vs propafenone	1.07	[0.06,17.89]
	Wang HP2012	3	60	1	60	Wenxin granules and propafenone vs propafenone	3.11	[0.31,30.73]
	Zhao S2013	6	70	3	70	Wenxin granules and propafenone vs propafenone	2.09	[0.50,8.73]
	I² = 0% ()						2.37	[0.85,6.60]
	Li ZM2010	6	77	12	51	Wenxin granules vs propafenone	0.27	[0.10,0.79]
	Meng FH2013	4	59	2	59	Wenxin granules vs propafenone	2.07	[0.36,11.78]
	I² = 74% ()						0.50	[0.21,1.15]

Abnormal sensation in the tongue	Shao MF2012	0	32	2	30	Wenxin granules and propafenone vs propafenone	0.18	[0.01,3.81]
	Not applicable						0.18	[0.01,3.81]
	Meng FH2013	0	59	2	59	Wenxin granules vs propafenone	0.19	[0.01,4.11]
	Not applicable						0.19	[0.01,4.11]

Frequent premature ventricular contraction	Li ZM2010	0	77	3	51	Wenxin granules vs propafenone	0.09	[0.00,1.77]
Frequent premature ventricular contraction	Not applicable						0.09	[0.00,1.77]

R-R interval prolongation	Li ZM2010	0	77	1	51	Wenxin granules vs propafenone	0.22	[0.01,5.44]
R-R interval prolongation	Not applicable						0.22	[0.01,5.44]