A Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke

Table 2

GO analysis was implemented on core targets.

Category	Term	Count	value
GOTERM BP DIRECT	GO:0045944-positive regulation of transcription from RNA polymerase II promoter	36	4.65E − 21
GOTERM BP DIRECT	GO:0045893-positive regulation of transcription, DNA-templated	28	2.78E − 20
GOTERM BP DIRECT	GO:0007568-aging	16	5.75E − 15
GOTERM BP DIRECT	GO:0042493-response to drug	19	1.64E − 14
GOTERM BP DIRECT	GO:1902895-positive regulation of pri-miRNA transcription from RNA polymerase II promoter	9	4.48E − 14
GOTERM BP DIRECT	GO:0010628-positive regulation of gene expression	17	3.44E − 13
GOTERM BP DIRECT	GO:0008217-regulation of blood pressure	11	1.16E − 12
GOTERM BP DIRECT	GO:0001666-response to hypoxia	14	4.59E − 12
GOTERM BP DIRECT	GO:0051091-positive regulation of sequence-specific DNA binding transcription factor activity	12	6.31E − 12
GOTERM BP DIRECT	GO:0043066-negative regulation of the apoptotic process	19	1.53E − 11
GOTERM MF DIRECT	GO:0008134-transcription factor binding	19	4.57E − 15
GOTERM MF DIRECT	GO:0019899-enzyme binding	19	7.25E − 14
GOTERM MF DIRECT	GO:0042802-identical protein binding	24	2.39E − 12
GOTERM MF DIRECT	GO:0005515-protein binding	77	2.53E − 12
GOTERM MF DIRECT	GO:0019901-protein kinase binding	16	7.65E − 10
GOTERM MF DIRECT	GO:0044212-transcription regulatory region DNA binding	13	9.23E − 10
GOTERM MF DIRECT	GO:0046982-protein heterodimerization activity	16	1.36E − 08
GOTERM MF DIRECT	GO:0003707-steroid hormone receptor activity	8	1.43E − 08
GOTERM MF DIRECT	GO:0005102-receptor binding	14	2.98E − 08
GOTERM MF DIRECT	GO:0000978-RNA polymerase II core promoter proximal region sequence-specific DNA binding	14	3.18E − 08
GOTERM CC DIRECT	GO:0005654-nucleoplasm	39	2.19E − 10
GOTERM CC DIRECT	GO:0005829-cytosol	41	2.37E − 09
GOTERM CC DIRECT	GO:0043234-protein complex	15	8.82E − 09
GOTERM CC DIRECT	GO:0005886-plasma membrane	45	1.05E − 08
GOTERM CC DIRECT	GO:0005615-extracellular space	25	1.06E − 08
GOTERM CC DIRECT	GO:0005576-extracellular region	27	1.66E − 08
GOTERM CC DIRECT	GO:0005901-caveola	8	2.46E − 08
GOTERM CC DIRECT	GO:0000790-nuclear chromatin	11	2.77E − 08
GOTERM CC DIRECT	GO:0043005-neuron projection	11	1.91E − 07
GOTERM CC DIRECT	GO:0005634-nucleus	46	1.36E − 05