Research Article
Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer
Figure 4
The mRNA expression of AKT, mTOR, P70S6, and VEGF in the marrow of tibia of mice with BMLC was measured by qPCR. (a) The AKT expression. (b) The mTOR expression. (c) The P70S6 expression. (d) The VEGF expression. Vehicle: BMLC mice treated with placebo (saline). L-D: BMLC mice treated with 15 g·kg−1·day−1 SLBZ-AP for 2 weeks. M-D: BMLC mice treated with 30 g·kg−1·day−1 SLBZ-AP for 2 weeks. H-D: BMLC mice treated with 60 g·kg−1·day−1 SLBZ-AP for 2 weeks. Rapamycin: BMLC mice treated with 4 mg·kg−1·day−1 rapamycin for 2 weeks.
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