| | Dose | Control | 1% GF | 2% GF | | Rat ID no. | 01 | 02 | 03 | 04 | 05 | 06 | 07 | 08 | 09 | 10 | 11 | 12 | 13 | 14 | 15 | 17 | 18 | 19 | 20 | 21 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 41 | | Tissue observation |
| | Ileum (H&E and Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | | Colon | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Increased height, villous | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | 1 | 1 | — | 1 | 1 | — | — | | Deposit, eosinophilic, lamina propria | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 3 | — | 2 | 3 | 3 | — | 3 | 3 | 2 | — | | Cell infiltration, mesocolon, focal | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | | Inflammation, mucosa, focal | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — | — | — | — | — | — | — | | Fibrosis, lamina propria (Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 3 | — | 2 | 3 | 3 | — | 3 | 3 | 2 | — | | Mesentery (H&E and Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | | Spleen | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Decreased pigmentation (hemosiderin) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 2 | — | 2 | 1 | 1 | 1 | — | 2 | 1 | — | | Liver | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Proliferation, bile duct | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 3 | 3 | 1 | | Cell infiltration (lymphoid cell), periportal | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 1 | — | — | — | — | — | — | — | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 3 | 2 | 1 | | Pigmentation (brown, granular), periportal | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — | — | — | — | — | — | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | | Pigmentation (brown, granular), hepatocyte | — | — | — | — | — | — | — | — | — | — | 1 | 1 | — | — | 1 | — | 1 | — | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 2 | 2 | | Atrophy, hepatocyte | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | | Decreased vacuole, periportal hepatocyte | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 3 | 2 | 2 | 3 | 3 | 3 | 3 | 2 | 2 | 2 | | Necrosis, focal | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — | — | 1 | — | | Inflammation, perivascular (portal vein), focal | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | | Kidney | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Mineralization, corticomedullary junction | — | — | — | — | 1 | 1 | 1 | — | 1 | 1 | 1 | — | 1 | — | 1 | 2 | 2 | — | — | 1 | 2 | 3 | 3 | 2 | 2 | 1 | 3 | 2 | 2 | 2 | | Pigmentation (brown, granular), proximal tubule | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 2 | | Cast | — | — | — | — | P | — | — | — | — | — | — | — | — | — | — | — | — | — | P | — | — | — | — | — | — | — | — | — | — | — | | Hyperplasia, urothelial, pelvis, focal | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — | — | — | — | — | — | — | — | — | | Regeneration, tubular | — | 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
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