Enriched-Baicalein Attenuates Allergy in Cells and Mice

Figure 3

Effect of baicalein on the histamine (a) and tryptase levels (b) in ovalbumin applied Balb/c mice. Six-week-old Balb/c males were used and ovalbumin was injected intraperitoneally for 0, 7, 14, 21, and 28 days to Balb/c (n = 5). The baicalein, containing 100 mg of baicalein·kg⁻¹ body weight per day dissolved in 0.4% polyethylene glycol in 0.5% EtOH, was applied topically on a daily basis for four weeks. Histamine and tryptase levels in the serum of mice were measured. The plasma histamine was analyzed by the fluorometric method with an AutoAnalyzer 3. Serum tryptase levels were measured with the B12 assay using ImmunoCAP Tryptase reagents and the Phadia 250 analysis device. All measurements were made in triplicate and all values are represented as mean ± SD. Nr, normal; OVA-CT, control treated with only ovalbumin; Dexa., dexamethasone; SB, Scutellaria baicalensis Georgi extract. and showed a significant difference from OVA-CT.

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