Effects of Aqueous and Methanolic Extracts of Stem Bark of Alstonia boonei De Wild. (Apocynaceae) on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Wistar Rats

Table 3

Effects of the aqueous and methanol stem-bark extracts of A. boonei on hematology in DSS-induced colitis in rats.

Treatment	Dose (mg/kg)	RBCs (million/μl)	WBCs (10^9/L)	Platelets (10^9/L)
Normal control	—	8.16 ± 0.15	4.90 ± 0.42	327.20 ± 13.53
DMSO (5 %) + PBS	—	6.08 ± 0.26^λ	10.45 ± 0.37^λ	744.20 ± 61.36^λ
Prednisolone	4	7.95 ± 0.40^c	8.24 ± 1.17^α	520.80 ± 57.62^αa
Aqueous extract	125	7.10 ± 0.10^αa	7.18 ± 0.79^a	460.20 ± 42.13^c
	250	7.64 ± 0.16^c	6.38 ± 0.70^b	468,60 ± 36.56^b
Methanol extract	125	7.37 ± 0.09^b	6.46 ± 0.38^b	490.20 ± 28.85^b
	250	7.67 ± 0.12^c	6.22 ± 0.43^b	410.60 ± 35.87^c

Values are expressed as mean ± SEM for six animals and analyzed by one-way ANOVA followed by Tukey post hoc test; , , : significant difference compared with DMSO + PBS; , : significant difference compared to normal control.