Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats

Table 4

Histopathological analysis of prostate tissue in rats with prostate cancer and treated with Cordia lutea for 5 months.

Group	Lumen	Epithelium	Layers	LG-PIN	HG-PIN
NS	Regular	Cubic	1	Negative	Negative
Induced cancer	Papillary	Columnar	>5	Positive ++/+++	Positive ++/+++
Cordia lutea 50 mg/kg	Papillary	Columnar	2–3	Positive ++/+++	Positive +/+++
Cordia lutea 250 mg/kg	Papillary	Columnar	2–3	Positive +/+++	Negative
Cordia lutea 500 mg/kg	Papillary	Columnar	1–2	Negative	Negative

NS = normal saline. HG-PIN = high-grade prostatic intraepithelial neoplasia. LG-PIN = low-grade prostatic intraepithelial neoplasia.