An In Vitro Study for Evaluating Permeability and Metabolism of Kurarinone

Figure 4

(a) Inhibitory effects of kurarinone (KU) on phenacetin (PHE) o-deethylation activity (CYP1A2). (b) Dixon plot of the inhibition effect of kurarinone on phenacetin o-deethylation (CYP1A2). (c) Lineweaver–Burk plot of the inhibitory effect of kurarinone on phenacetin o-deethylation (CYP1A2). (d) Secondary plot of slopes from the Lineweaver–Burk plot versus kurarinone concentrations. Each data points represent mean of two replicates.

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