An In Vitro Study for Evaluating Permeability and Metabolism of Kurarinone

Table 1

Kinetic parameters of produced from kurarinone in pooled CYP1A2, CYP2D6, MLMs, HLMs, PLMs, and RLMs.

	CYP1A2^a	CYP2D6^a	MLMs^b	HLMs^b	PLMs^b	RLMs^b
Km	9.45 ± 2.11	13.76 ± 3.09	21.02 ± 3.42	21.96 ± 4.93	49.91 ± 7.91	18.08 ± 3.91
	2.45 ± 0.25	2.78 ± 0.36	4.83 ± 0.14	1.56 ± 0.24	8.46 ± 0.74	3.34 ± 0.19
CLint	0.26	0.21	0.23	0.07	0.17	0.18

^aK_m, , and CL_int are expressed in units of μM, μmol·min⁻¹·nmol⁻¹ CYP, and mL·min⁻¹·pmol⁻¹ CYP, respectively. ^bK_m, , and CL_int are expressed in units of μM, nmol·min⁻¹·mg⁻¹ protein, and mL·min⁻¹·mg⁻¹ protein, respectively.