Evaluation of the Antimalarial Activity of the Hydroalcoholic Extract of Leaf of Leonotis ocymifolia (Burm. f.) Iwarsson (Lamiaceae) against Plasmodium berghei in Mice

Table 2

Body weight, rectal temperature, and packed cell volume of P. berghei-infected Swiss albino mice treated with hydroalcoholic extract of leaf of Leonotis ocymifolia in the four-day suppressive test.

Treatment	Weight			Packed cell volume (PCV)
	D0	D4	Change (%)	D0	D4	Change (%)
CON	31.521.91	29.011.70	−7.72	53.483.01	49.243.10	−8.11
HA 100 mg/kg	34.061.14	31.400.78	−7.59	52.130.87	47.980.99	−8.33
HA 200 mg/kg	28.991.04	27.100.99	−6.51	54.281.51	50.311.89	−7.21
HA 400 mg/kg	33.551.06	32.460.90	−3.11	52.311.47	49.901.14	−4.43
HA 800 mg/kg	33.051.82	31.721.69	−3.97	54.401.47	51.551.68	−5.28
CQ 25 mg/kg	31.520.61	31.571.46	0.31^a2c2d2	54.161.31	53.841.16	−0.51^a1c1d1

Data are expressed as mean ± SEM (n = 8); ^acompared to negative control; ^bcompared to CQ 25 mg/kg; ^ccompared to 100 mg/kg; ^dcompared to 200 mg/kg; ^ecompared to 400 mg/kg; ^fcompared to 800 mg/kg:  < 0.05,  < 0.01, and  < 0.001; HA, hydroalcoholic; negative controls received 2% Tween 80 in water; CON, negative control; CQ, chloroquine.