Review Article

Acupuncture for Cancer-Induced Bone Pain in Animal Models: A Systemic Review and Meta-Analysis

Table 2

Characteristics of included studies.

Study IDTreatment/No.Control/No.AcupointsStimulator parametersNo. of treatmentsOutcomesSide effects

Qiliang [20]EA(12)
EA + celecoxib(12)
Model(10)
model + celecoxib(12)
ST36, BL60QID, 4/60HZ, 1 mA, 30 min/time10PWT, PWL BWNR > 0.05
 < 0.05
Zhang et al. [21]EA(7)SEA(7)GB30QD, 10 Hz/2 mA, 30 min/time5PWLIL-1βNR < 0.05
Zhang et al. [23]EA(7)SEA(7)GB30QD,10 Hz/2 mA, 30 min/time5PWLPWPTNR < 0.05
Qiliang et al. [22]EA(12)
EA + celecoxib (12)
Model(12)
Celecoxib(12)
ST36, BL60QD, 4/Hz,1 mA,30 min/time20PWTNR < 0.05
Li [24]EA(16)
EA
Model(8)
Model
ST36/BL60 and ST36/GB30
ST36/GB30
QID,15 Hz, 2-5 mA, 30 min/time, 15 Hz,2-5 mA, 30 min/time,6PWTNR > 0.05
10PWT > 0.05
Smeester et al. [25]EA(97)Model(39)
Sham EA(67)
ST362/week,4 Hz,30 min/time6PWTNR < 0.01
Kuai et al. [26]EA(20)Model(10)
Morphine(10)
L3-L5 JiajiQD,2/100 Hz,30 min/time6PWLNR < 0.01
Zhao et al. [28]EA(10)model(10)BL2QD,2/100 Hz, 0.3 mA,13 min/time12PWT, PWL, BWNR < 0.05
Zhao et al. [29]EA(8)
EA(8)
EA + Zoledronic acid(8)
Model(8)
Zoledronic acid(8)
Zoledronic acid(8)
BL2QD,2/100 Hz, 3 mA, 6.5 min/time12BW, PWL PWTNR < 0.05
Si-ma et al. [27]EA(20)Morphine(10)ST36, SP6QD,2/100 Hz,0.5–1.5 mA, 30 min/time9PWTNR < 0.01
Du et al. [30]EA(42)Model(7)ST36, BL601-2 mA,30 min/time7PWTNR < 0.01
Du et al. [31]EA(8)Model (8)ST36, GenDuanQID,2 Hz,1-2 mA,30 min/time7PWTNR < 0.05
Lu et al. [32]EA(12)
EA + morphine(12)
Model(12)
Morphine(12)
L3-5JiaJiQD, 2/100 Hz, 2 mA, 30 min/time6PWL, GFAP, IL-1βNR < 0.01
Lu et al. [33]EA(8)Model(8)L3-5JiaJiQD, 2/100 Hz, 30 min/time6PWLNR < 0.05
Sima et al. [34]EA(8)
EA + morphine
tolerance(8)
SEA(8)
Model(8)
Morphine tolerance
ST36, SP6QD,2/100 Hz, 0.5–1.5 mA, 30 min/time9PWTNR < 0.01
Fu et al. [35]EA I (8)
EA II (8)
Model(8)
Morphine tolerance(8)
SEA(11)
ST36, BL60QD,2/100 Hz, 2/100 Hz, 0.5–1.5 mA, 30 min/time7/18PWTNR < 0.05
Fu et al. [36]EA(6)Model(8)
Morphine tolerance(8)
SEA(6)
ST36, BL60QD, 2/100 Hz, 0.5–1.5 mA, 30 min/time7PWTNR < 0.01
Guan et al. [37]EA + herbal plaster (20)Herbal plaster(20)ST36, BL60QID, 2/100 Hz, 30 min/time,6PWT, IL-1βNR < 0.05
Liang et al. [39]EA(15)Model(13)
Morphine(13)
ST36, BL60QID, 2/100 Hz, 0.5-1.0-1.5 mA,30 min/time8PWTNR < 0.01
Liang et al. [38]EA(13)Model(10)
Morphine(10)
ST36, BL60QID, 2/100 Hz, 0.5–1.5 mA, 30 min/time8PWTNR < 0.01
Qin et al. [40]EA(12)
EA + Herbal plaster(12)
Model(12)
plaster(12)
ST36, BL60QD, 2/100 Hz,0.5–1.5mA30 min/time12PWL, PWTNR < 0.01
Cai et al. [41]EA(13)Model(10)
Morphine(10)
ST-36, BL60QID,2/100 Hz,0.5–1.5 mA,30 min/time8PWT, BWNR < 0.05
Shi et al. [42]EA(11)Model(8)
Morphine tolerance(11)
SEA(9)
ST-36, BL60QD, 2/100 Hz,0.5–1.5 mA, 30 min/time7PWTNR < 0.05
Guan et al. [43]EA + herbal medicine (20)Herbal medicine (20)ST36, GenDuanQD,1-2 mA,30 min/time20BW, PWLNR < 0.05

EA = electroacupuncture; PWT = paw withdrawal threshold; PWL = paw withdrawal latency; BW = body weight; PWPT = paw withdrawal pressure threshold; GFAP = glial fibrillary acidic protein; IL-1β = interleukin-1β; NR = no report.