Acute Oral Toxicity and Anti-inflammatory and Analgesic Effects of Aqueous and Methanolic Stem Bark Extracts of Piliostigma thonningii (Schumach.)

Table 1

Effects of the aqueous stem bark extract of P. thonningii on acetic acid-induced writhing in mice.

Dose (mg/kg bw)	Aqueous stem bark extract of P. thonningii
	Writhing frequency	% inhibition
4	66.20 ± 1.16^b	29.72
20	56.40 ± 2.04^c	40.13
100	24.80 ± 1.86^d	73.67
500	14.00 ± 1.14^e	85.14
Acetylsalicylic acid (75 mg/kg bw)	15.40 ± 1.21^e	83.65
Negative control	94.20 ± 3.97^a	0

Values are presented as mean ± SEM; means with different superscript letters along the column are significantly different (One-Way ANOVA followed by Tukey’s test; ).