Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 1 / Review Article
Effect of Moxibustion on Inflammatory Cytokines in Animals with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Table 1 Characteristics of the 18 included studies.
Study Species (Nc /Nm ) Gender Age (week) Weight (g) Model Moxibustin (acupoints) Control Duration (day) Outcome index Zhang 2018 [15 ] SD rat (8/8) Male NR 200–250 CIA SM (BL23, ST36) No treatment 21 TNF-α ; IL-1β Gao et al. 2017 [16 ] SD rat (8/9) Male Adult 200 ± 20 CFA SSMC (BL23, ST36) No treatment 21 TNF-α ; IL-1β ; IL-17 Wang et al. 2017 [17 ] SD rat (8/8) Male NR 200 ± 20 CIA SM (BL23, ST36) No treatment 21 TNF-α ; IL-1β Wu et al. 2017 [18 ] SD rat (8/8) Male 7-8 NR CIA SM (BL23, ST36) No treatment 21 TNF-α ; IL-1β Su et al. 2015 [19 ] SD rat (10/10) Male/female 8–10 200 ± 20 CFA TYM governor meridian No treatment 12 TNF-α Wu et al. 2018 [20 ] SD rat (24/24) Male/female Adult 180 ± 20 CFA SSMC (BL23, ST36) No treatment 21 TNF-α Fan et al. 2017 [21 ] SD rat (10/10) Male NR 200 ± 20 CFA SM (BL23, ST36, GB34) No treatment 21 TNF-α ; IL-6 Cui 2019 [22 ] Wistar rat (8/8) Male NR 140 ± 15 CIA + CFA SSMC (BL23, ST36, SP9, GB34) No treatment 20 TNF-α Huo et al. 2020 [23 ] Wistar rat (10/10) Male/female NR 180 ± 20 CFA SM (BL23, ST36) No treatment 21 TNF-α ; IL-1β ; IFN-γ ; IL-4 Yin et al. 2017 [24 ] Wistar rat (10/10) Male NR 125 ± 15 CIA SM (BL23, ST36) No treatment 16 TNF-α ; IL-17 Luo et al. 2011 [25 ] Wistar rat (20/20) Male 12–16 200 ± 20 CFA SM (BL23, ST36) No treatment 15 TNF-α ; IL-1β ; IL-2 Wu et al. 2018 [26 ] SD rat (24/24) Male/female Adult 200 ± 20 CFA SSMC (BL23, ST36) No treatment 21 IL-1β ; IL-6 Gao et al. 2011 [27 ] SD rat (10/10) Male NR 200 ± 20 CFA SSMC (BL23, ST36) No treatment 21 IL-1β ; IL-4 Zhang et al. 2014 [28 ] Wistar rat (8/8) Male 12–16 160–180 CFA SSMC (BL23, behind BL23) No treatment 20 IL-2 Bao 2007 [29 ] SD rat (10/10) Male/female NR 200 ± 20 CFA TM (CV4, GV4) No treatment 25 IL-2 Lai 2018 [30 ] SD rat (15/15) Male/female Adult 200 ± 20 CFA SSMC (BL23, ST36) No treatment 21 IL-4; IL-10; IFN-γ Ma et al. 2016 [31 ] SD rat (24/24) Male/female Adult 200 ± 20 CFA SSMC (BL23, ST36) No treatment 21 IL-6 Ren et al. 2019 [32 ] SD rat (15/15) Male/female NR 200 ± 20 CFA SSMC (BL23, ST36) No treatment 21 IFN-γ ; IL-10
Nm : number of animals in the moxibustion group, Nc : number of animals in the control group, SD sprague dawley, NR : no record, CIA : collagen-induced arthritis, CFA : complete Freund’s adjuvant, SM : suspension moxibustion, SSMC : seed-sized moxa cone, and TYM : tai-yi moxibustion.
