Hepatoprotective Effect of Pericarpium zanthoxyli Extract Is Mediated via Antagonism of Oxidative Stress

Table 3

Immunohistochemical-histomorphometrical analysis of acute CCl₄-treated mouse hepatic tissues.

Groups	Positive cells by immunohistochemistry (cells/1000 hepatocytes)
	Cleaved caspase-3	Cleaved poly (ADP-ribose) polymerase	Nitrotyrosine	4-Hydroxynonenal
Control	12.20 ± 9.18	19.80 ± 10.94	28.40 ± 18.22	62.40 ± 30.66
PZE 300	12.00 ± 7.65	19.40 ± 9.66	27.20 ± 20.75	61.40 ± 37.58
CCl4	664.60 ± 77.89^c	713.40 ± 57.50^c	664.20 ± 50.00^c	795.60 ± 60.11^a
CCl4 + silymarin	420.00 ± 33.13^cd	463.80 ± 57.12^cd	388.40 ± 69.68^cd	404.40 ± 51.03^ab
CCl4 + PZE 100	433.20 ± 89.18^cd	461.20 ± 77.33^cd	412.80 ± 133.19^ce	427.20 ± 83.58^ab
CCl4 + PZE 300	261.80 ± 50.98^cd	284.00 ± 108.91^cd	217.20 ± 37.10^cd	278.60 ± 45.39^ab

^a as compared with control by LSD test, ^b as compared with CCl₄ by LSD test, ^c as compared with control by MW test, ^d and ^e as compared with CCl₄ by MW test.