Research Article

Deciphering the Underlying Mechanism of Eucommiae Cortex against Osteoporotic Fracture by Network Pharmacology

Table 1

Information of 64 hub targets.

UniProt IDGene symbolDescriptionDegree

Q499G7MAPK1Mitogen-activated protein kinase 141
P12931SRCSRC proto-oncogene, non–receptor tyrosine kinase39
P27986PIK3R1Phosphoinositide-3-kinase regulatory subunit 136
P15692VEGFAVascular endothelial growth factor A31
Q53GA5TP53Tumor protein p5329
Q504U8EGFREpidermal growth factor receptor29
P05412JUNJun proto-oncogene29
P01019AGTAngiotensinogen29
Q75MH2IL6Interleukin 628
P01133EGFEpidermal growth factor27
P45983MAPK8Mitogen-activated protein kinase 826
Q6FG41FOSFos proto-oncogene25
P00734F2Coagulation factor II, thrombin25
Q9UQS6FN1Fibronectin 124
Q6FH53EDN1Endothelin 124
Q5STB3TNFTumor necrosis factor24
P02775PPBPPro-platelet basic protein24
Q9UBT1ESR1Estrogen receptor 123
Q15788NCOA1Nuclear receptor coactivator 123
P35222CTNNB1Catenin beta 123
P04150NR3C1Nuclear receptor subfamily 3 group C member 123
P02768ALBAlbumin22
Q6P3U7RXRARetinoid X receptor alpha21
P22681CBLCbl proto-oncogene21
P01308INSInsulin20
P17612PRKACAProtein kinase cAMP-activated catalytic subunit alpha18
P02765AHSGAlpha 2-HS glycoprotein18
P01137TGFB1Transforming growth factor beta 118
V9HW22HSPA8Heat shock protein family A (Hsp70) member 817
Q9NUA2ARAndrogen receptor17
Q9GZV9FGF23Fibroblast growth factor 2317
Q5JWF2GNASGNAS complex locus16
P19838NFKB1Nuclear factor kappa B subunit 116
Q14393GAS6Growth arrest specific 615
Q05655PRKCDProtein kinase C delta15
P30518AVPR2Arginine vasopressin receptor 215
P02647APOA1Apolipoprotein A115
P01127PDGFBPlatelet-derived growth factor subunit B15
Q6PK50HSP90AB1Heat shock protein 90 alpha family class B member 114
Q5FC01IL4Interleukin 414
P0DMV9HSPA1AHeat shock protein family A (Hsp70) member 1A14
P01344IGF2Insulin-like growth factor 214
Q96EB6SIRT1Sirtuin 113
Q4W448PPARGPeroxisome proliferator activated receptor gamma13
Q07869PPARAPeroxisome proliferator activated receptor alpha13
P60953CDC42Cell division cycle 4213
P06401PGRProgesterone receptor13
P01579IFNGInterferon gamma13
P01034CST3Cystatin C13
Q9Y6Q9NCOA3Nuclear receptor coactivator 312
Q9Y494TAC1Tachykinin precursor 112
Q9NQ66PLCB1Phospholipase C beta 112
P29474NOS3Nitric oxide synthase 312
P13501CCL5C-C motif chemokine ligand 512
P09038FGF2Fibroblast growth factor 212
Q92731ESR2Estrogen receptor 211
Q59GY7STAT5ASignal transducer and activator of transcription 5A11
P41221WNT5AWnt family member 5A11
P28335HTR2C5-Hydroxytryptamine receptor 2C11
P28223HTR2A5-Hydroxytryptamine receptor 2A11
P13500CCL2C-C motif chemokine ligand 211
P06850CRHCorticotropin releasing hormone11
P02649APOEApolipoprotein E11
P00746CFDComplement factor D11