Evidence-Based Complementary and Alternative Medicine

Research Article

Mechanisms and Molecular Targets of the Tao-Hong-Si-Wu-Tang Formula for Treatment of Osteonecrosis of Femoral Head: A Network Pharmacology Study

Table 2

The list of targets and active compounds of Tao-Hong-Si-Wu-Tang formula against ONFH.
TCMSP IDChemical compoundHerb sourceTarget
MOL000006LuteolinCarthami FlosPTGS2, PRSS1, RELA, VEGFA, CCND1, MMP2, RB1, JUN, IL6, MMP1, PCNA, MCL1, PTGES, MET
MOL000296HederageninPersicae SemenADH1C, SCN5A, PTGS2
MOL000358Gibberellin 7Paeoniae Radix Alba, Angelicae Sinensis Radix, Carthami Flos, Persicae SemenPTGS2, SCN5A, CHRM4, ADRA1A, OPRM1, JUN, PRKCA
MOL000422KaempferolPaeoniae Radix Alba, Carthami FlosPTGS2, PRSS1, ACHE, F7, CALM1, RELA, JUN, MMP1, STAT1, VCAM1, CYP1B1, ALOX5, HAS2, AHR, NR1I3
MOL000449StigmasterolRehmanniae Radix Praeparata, Angelicae Sinensis Radix, Carthami FlosADH1C, PTGS2, SCN5A, ADRA1A
MOL000492(+)-catechinPaeoniae Radix AlbaPTGS2, CALM1, HAS2
MOL000493CampesterolPersicae SemenPTGS2
MOL001323Sitosterol alpha1Persicae SemenPTGS2, ADH1C
MOL0013282,3-didehydro GA70Persicae SemenPTGS2, PRSS1
MOL0013292,3-didehydro GA77Persicae SemenPTGS2
MOL001340GA120Persicae SemenPTGS2
MOL001352GA54Persicae SemenPTGS2, CALM1
MOL001355GA63Persicae SemenPTGS2
MOL001358Gibberellin 7Persicae SemenPTGS2
MOL001361GA87Persicae SemenPTGS2
MOL0013683-O-p-coumaroylquinic acidPersicae SemenPTGS2, CALM1
MOL001494MandenolChuanxiong RhizomaPTGS2
MOL001924PaeoniflorinPaeoniae Radix AlbaIL6, CD14, LBP
MOL002135MyricanoneChuanxiong RhizomaSCN5A, PTGS2, F7
MOL002140PerlolyrineChuanxiong RhizomaPTGS2
MOL002157WallichilideChuanxiong RhizomaPTGS2, NR3C1
MOL0026944-[(E)-4-(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene) but-2-enylidene]-2,6-dimethoxycyclohexa-2,5-dien-1-oneCarthami FlosPTGS2
MOL002695LignanCarthami FlosPTGS2, CALM1
MOL002710Pyrethrin IICarthami FlosPTGS2
MOL0027126-hydroxykaempferolCarthami FlosPTGS2, PRSS1
MOL002714BaicaleinCarthami FlosPTGS2, PRSS1, CALM1, RELA, VEGFA, AHR, EGLN1, APOD
MOL002717qt_carthamoneCarthami FlosPTGS2
MOL002721QuercetagetinCarthami FlosPTGS2, PRSS1
MOL0027577,8-dimethyl-1H-pyrimido[5,6-g]quinoxaline-2,4-dioneCarthami FlosPTGS2
MOL002773Beta-caroteneCarthami FlosVEGFA, MMP2, JUN, PTGS2, MMP1, CAV1, GJA1