Protective Effects of Phellinus linteus Mycelium on the Development of Osteoarthritis after Monosodium Iodoacetate Injection

Figure 4

iNOS, and COX-2, TNF-α, IL-6, and IL-1β protein expressions in cartilage tissues. Values are the mean ± SEM (n = 6). Nor: normal rats; Con: MIA-induced osteoarthritis rats; GLM200: MIA-induced osteoarthritis rats administrated with green-lipped mussel 200 mg/kg body weight; PLM50: MIA-induced osteoarthritis rats administrated with PLM 50 mg/kg body weight; PLM100: MIA-induced osteoarthritis rats administrated with PLM 100 mg/kg body weight; PLM200: MIA-induced osteoarthritis rats administrated with PLM 200 mg/kg body weight. Significance: ^##P < 0.01: ^###P < 0.001 vs. normal rat values and ^∗P < 0.05: ^∗∗P < 0.01: ^∗∗∗P < 0.001 vs. MIA control rat values.