STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report

Table 2

Effects of STW1 and its individual herbal extracts in different in situ/in vivo models of inflammation, edema, pain, and fever (semiquantitative assessment).

Models

Phenylquinonewrithing test (analgesic effect)

Carrageenan-induced paw edema (anti-inflammatory/antiexudative effect)

Adjuvant-induced arthritis (antiproliferative/anti-inflammatory effect)

Dextran rat paw edema (antiexudative/anti-inflammatory effect)

Inhibition of the generation of inflammatory mediators

Brewer’s yeast-induced pyrexia (ant-pyretic/analgesic effect)

Cotton pellet test (antiproliferative/anti-inflammatory effect)

Total x

Ear

Lung

Granulocytes

PGs

HIST

PGs

LTs

LTB4

5-HETE

References

RR 03/84, 01/85, and 24/89

RR 04/85, 15/87, and 26/89 [8]

RR 04/85, 15/87, and 26/89 [8]

RR 13/87 and 14/87 [8]

RR03/89 and 20/89

RR 7/90 and 17/91

RR 23/89

RR 04/86, 12/87, 21/88, 27/89, 03/90, and 04/90

RR 05/85

STW1

x

xx

xx

xx

x

X

xx

x

x

x

Xx

xx

18

Populus tr.

xx

x

(x)

x

xx

xx

(x)

xx

xx

x

X

(x)

15.5

Fraxinus exc.

x

x

x

x

x

(x)

x

xx

(x)

(x)

X

x

11.5

Solidago vir.

x

x

x

x

o

xx

x

(x)

x

xx

X

(x)

12

Effects of aqueous-alcoholic and of dry extracts. Effects of aqueous-alcoholic extracts. HIST = histamine; PGs = prostaglandins; LTs = leukotrienes; LTB₄ = leukotriene B₄; 5-HETE = 5-hydroxy-eicosatetraenoic acid; RR = research report; xx = strongest effect; xx = strong effect; x = medium effect; (x) = slight effect; O = no effect.