Research Article
Effect of Cellgevity® Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity and Pharmacokinetic Parameters of Carbamazepine
Table 1
Summary of the effect of Cellgevity® on selected rat CYP enzyme activity.
| | CYP isoform | Assay | Effect of Cellgevity® on CYP activity |
| | CYP3A4 | BROD | No significant increase in enzyme activity | | CYP2B1/2 | PROD | No significant increase in enzyme activity | | CYP1A1/2 | MROD | Significant increase in enzyme activity (H-D: ) | | CYP2C9 | Diclofenac hydroxylation | Significant increase in enzyme activity (L-D: ; M-D and H-D: ) | | CYP2D6 | Dextromethorphan O-Demethylation | Significant increase in enzyme activity (L-D and M-D: ; H-D: ) |
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L-D = Low dose (38.63 mg/kg) of Cellgevity®; M-D = Medium dose (77.25 mg/kg) of Cellgevity®; H-D = High dose (154.50 mg/kg) of Cellgevity®.
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