Antimetastatic Potential of Rhodomyrtone on Human Chondrosarcoma SW1353 Cells
Antimigration of rhodomyrtone was determined by wound healing and transwell chamber assay. (a) The wound areas were created by a sterile micropipette tip and treated with or without the subcytotoxic concentrations of rhodomyrtone for 24 h. Cell migration of SW1353 cells was captured under a 40x magnification of the microscope. (b) The wound closure was analyzed by measuring the area between the edges (white lines indicated the wound edge). (c) Rhodomyrtone also significantly suppressed cell migration in a dose-dependent manner as detected with the transwell chamber. (d) Quantitative analysis of the migratory cells was calculated by NIH ImageJ. Data represent mean ± standard deviation (SD) from three independent experiments. vs. untreated control.
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