Yiqi Yangyin Huoxue Method in Treating IdiopathicPulmonary Fibrosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 4

Statement of facts for all outcomes.

YQYYHXM plus CWM vs. CWM
Patient or population: patients with idiopathic pulmonary fibrosis; setting: all eligible patients with intervention therapy
Intervention: (YQYYHXM, CWM)
Outcome	No. of participants (RCTs)	Relative effect (95% CI)	Anticipated absolute effects (95% CI)		Quality of the evidence
			CWM	CWM + YQYYHXM	(GRADE)
Change of cough; Follow-up: 2–12 days	363; (6 RCTs)		The mean of change of cough was 1.08 to 3.73	MD 0.71 lower (1.21 to 0.21 lower)	⊕⊕⊕Ο moderate^ab
Changes of chest pain; Follow-up: 8–12 days	286; (5 RCTs)		The mean of chest pain was 1.63 to 2.93	MD 0.46 lower (0.7 to 0.21 lower)	⊕⊕ΟΟ low
Changes in shortness of breath; Follow-up:2–12 days	363; (6 RCTs)		The mean of shortness of breath was 0.79 to 7.95	MD 0.38 lower (0.62 to 0.14 lower)	⊕⊕⊕Ο moderate^a
FVC; Follow-up: 12 days	176; (4 RCTs)		The mean of FVC was 62.92 to 72.25	MD 1.52 higher (2.72 lower to 5.76 higher)	⊕⊕ΟΟ low^a
TLC; Follow-up: 12 days	270; (6 RCTs)		The mean of TLC was 47.84 to 62.57	MD 2.22 lower (4.2 to 0.24 lower)	⊕⊕ΟΟ low^ac
PO2; Follow-up: 12 days	166; (4 RCTs)		The mean of PO2 was 77.46 to 77.67	MD 2.01 higher (0.2 lower to 4.23 higher)	⊕⊕⊕Ο moderate^a
6MWD; Follow-up: 2–12days	343; (5 RCTs)		The mean of 6MWD was 331 to 350.5	MD 87.96 higher (86.71 to 89.21 higher)	⊕⊕⊕Ο moderate^ac
SGRQ; Follow-up:2–12 days	206; (5 RCTs)	OR 3.6 (1.52 to 8.51)	The mean of SGRQ 114 per 1000 (50 to 144)	151 per 1000 (65 to 192)	⊕ΟΟΟ very low^a

GRADE Working Group grades of evidence. High quality: we are extremely confident for that the effect estimation lies close to true effect. Moderate quality: we have enough confidence for that effect estimation is likely to be close to the true effect. Low quality: we maintain partial confidence for that effect estimation may be obviously different from true effect. Very low quality: we have little confidence for that effect estimation is likely to be obviously different from true effect. Explanations. _aNo blinding. _bHigh heterogeneity. in Egger’s test.