Research Article
A Comprehensive Toxicological Assessment of Fulvic Acid
Table 3
The effects of FA on hematology parameters of rats in the 60-day subchronic toxicity assay.
| Parameters | HG (g/L) | RBC (M/mm3) | WBC (th/mm3) | PLT (th/mm3) | F | M | F | M | F | M | F | M |
| 30-day | 0.5% CMC-Na | 160.20 ± 6.97 | 158.60 ± 5.08 | 7.64 ± 0.53 | 7.66 ± 0.50 | 8.40 ± 0.59 | 8.15 ± 0.88 | 471.60 ± 67.92 | 465.00 ± 61.30 | 2 00 mg/kg BW | 158.8 ± 4.83 | 153.2 ± 5.81 | 7.71 ± 0.35 | 7.38 ± 0.38 | 7.62 ± 0.5 | 8.61 ± 0.43 | 443.2 ± 71.3 | 461 ± 57.69 | 1 000 mg/kg BW | 157.40 ± 7.94 | 157.00 ± 10.49 | 7.14 ± 0.42 | 7.03 ± 0.43 | 8.03 ± 0.83 | 8.20 ± 0.83 | 459.20 ± 58.31 | 449.80 ± 42.56 | 5 000 mg/kg BW | 157.80 ± 6.85 | 152.80 ± 5.49 | 7.20 ± 0.59 | 7.77 ± 0.40 | 8.22 ± 0.81 | 7.98 ± 0.78 | 473.00 ± 66.21 | 453.80 ± 89.35 |
| 60-day | 0.5% CMC-Na | 146.00 ± 9.86 | 151.60 ± 11.15 | 7.72 ± 0.53 | 8.01 ± 0.51 | 7.72 ± 0.53 | 8.09 ± 0.55 | 368.80 ± 67.42 | 368.60 ± 58.6 | 200 mg/kg BW | 147.6 ± 9.2 | 153 ± 10.18 | 7.51 ± 0.5 | 7.76 ± 0.37 | 7.62 ± 0.5 | 7.76 ± 0.37 | 393.8 ± 53.93 | 372.8 ± 57.03 | 1,000 mg/kg BW | 149.60 ± 8.87 | 148.60 ± 12.32 | 7.14 ± 0.42 | 7.94 ± 0.51 | 8.02 ± 0.83 | 8.11 ± 1.13 | 384.60 ± 58.82 | 362.00 ± 80.19 | 5,000 mg/kg BW | 149 ± 12.5 | 145.66 ± 9.41 | 7.71 ± 0.50 | 7.98 ± 0.76 | 7.82 ± 0.73 | 8.19 ± 0.53 | 384.00 ± 49.52 | 398.60 ± 54.04 |
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No statistically significant differences were found. CMC-Na, carboxyl methyl cellulose sodium; HG, hemoglobin concentration; RBC, red blood cell count; WBC, white blood cell count; PLT, platelet count; F, female; M, male.
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