A Comprehensive Toxicological Assessment of Fulvic Acid

Table 3

The effects of FA on hematology parameters of rats in the 60-day subchronic toxicity assay.

Parameters	HG (g/L)		RBC (M/mm^3)		WBC (th/mm^3)		PLT (th/mm^3)
	F	M	F	M	F	M	F	M
30-day
0.5% CMC-Na	160.20 ± 6.97	158.60 ± 5.08	7.64 ± 0.53	7.66 ± 0.50	8.40 ± 0.59	8.15 ± 0.88	471.60 ± 67.92	465.00 ± 61.30
2 00 mg/kg BW	158.8 ± 4.83	153.2 ± 5.81	7.71 ± 0.35	7.38 ± 0.38	7.62 ± 0.5	8.61 ± 0.43	443.2 ± 71.3	461 ± 57.69
1 000 mg/kg BW	157.40 ± 7.94	157.00 ± 10.49	7.14 ± 0.42	7.03 ± 0.43	8.03 ± 0.83	8.20 ± 0.83	459.20 ± 58.31	449.80 ± 42.56
5 000 mg/kg BW	157.80 ± 6.85	152.80 ± 5.49	7.20 ± 0.59	7.77 ± 0.40	8.22 ± 0.81	7.98 ± 0.78	473.00 ± 66.21	453.80 ± 89.35
60-day
0.5% CMC-Na	146.00 ± 9.86	151.60 ± 11.15	7.72 ± 0.53	8.01 ± 0.51	7.72 ± 0.53	8.09 ± 0.55	368.80 ± 67.42	368.60 ± 58.6
200 mg/kg BW	147.6 ± 9.2	153 ± 10.18	7.51 ± 0.5	7.76 ± 0.37	7.62 ± 0.5	7.76 ± 0.37	393.8 ± 53.93	372.8 ± 57.03
1,000 mg/kg BW	149.60 ± 8.87	148.60 ± 12.32	7.14 ± 0.42	7.94 ± 0.51	8.02 ± 0.83	8.11 ± 1.13	384.60 ± 58.82	362.00 ± 80.19
5,000 mg/kg BW	149 ± 12.5	145.66 ± 9.41	7.71 ± 0.50	7.98 ± 0.76	7.82 ± 0.73	8.19 ± 0.53	384.00 ± 49.52	398.60 ± 54.04

No statistically significant differences were found. CMC-Na, carboxyl methyl cellulose sodium; HG, hemoglobin concentration; RBC, red blood cell count; WBC, white blood cell count; PLT, platelet count; F, female; M, male.