Qingxin Kaiqiao Fang Inhibits A<i>β</i><sub>25-35</sub>-Induced Apoptosis in Primary Cultured Rat Hippocampal Neuronal Cells via the p38 MAPK Pathway: An Experimental Validation and Network Pharmacology Study

<div>25 mg mL<sup>−1</sup> QKF alleviates neuronal apoptosis by p38 MAPK silencing. (a) TUNEL staining in each group of hippocampal neurons (original magnification, ×200). (b) Statistical analysis results of TUNEL staining. (c) The gray value of associated proteins in each group. (d) Relative protein expression in each group, as detected by WB analysis. 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transform="matrix(.013,0,0,-0.013,40.821,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,43.785,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,50.025,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> QKF, Qingxin kaiqiao fang.</div>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: Qingxin Kaiqiao Fang Inhibits A<i>β</i><sub>25-35</sub>-Induced Apoptosis in Primary Cultured Rat Hippocampal Neuronal Cells via the p38 MAPK Pathway: An Experimental Validation and Network Pharmacology Study 

Figure 7 | Qingxin Kaiqiao Fang Inhibits Aβ25-35-Induced Apoptosis in Primary Cultured Rat Hippocampal Neuronal Cells via the p38 MAPK Pathway: An Experimental Validation and Network Pharmacology Study 