Review Article

Qiju Dihuang Decoction for Hypertension: A Systematic Review and Meta-Analysis

Table 1

Characteristic of the 19 trials included in the meta-analysis.

Author(s)Sample size (experimental/control)Gender (male/female)Diagnostic criteriaExperimentalControlDurationOutcome measures

Du et al. [20]60/6066/54WHO-ISHNGMH-1999QDD (6 g, tid) + CFelodipine sustained release tablet (5 mg, qd)1 monthBP, Ang II, ET
Du et al. [21]30/3031/29DCPTHCQDD (9 g, bid) + CNifedipine delayed-release tablet (30 mg, qd)1 monthAE, BP
Guo and Li [22]40/4046/34DCPTHCModified QDD (1 dose/d) + CNifedipine delayed-release tablet (10 mg, bid), captopril tablet (25 mg, bid)1 monthAE, BP
Huang [23]40/40NRDCPTHCQDD (9 g, bid) + CNifedipine tablet (30 mg, qd)1 monthAE, BP
Liang [24]133/132128/137WHO-ISHNGMH-1999QDD (6 g, bid) + CCADLI6 monthsAE
Li et al. [25]50/5049/51WHO-ISHNGMH-1999Modified QDD (1 dose/d)Conventional treatment (nao liqing, luo buma tablet, and dihydrochlorothiazide)3 monthsAE
Liu [26]50/5047/53WHO-ISHNGMH-1999Modified QDD (1 dose/d) + CAmlodipine besylate tablet (5 mg, qd)1 monthBP, CE, QL
Liu et al. [27]219/114159/174GDTCDIMCMModified QDD (1 dose/d)Conventional treatment (nao liqing, luo buma tablet, and dihydrochlorothiazide)3 monthsAE
Lu [28]40/4048/32WHO-ISHNGMH-1999Modified QDD (1 dose/d)Captopril tablet (25 mg, tid)NRAE
Luo and Luo [29]60/6065/55WHO-ISHNGMH-1999Modified QDD (1 dose/d)Nitrondipine tablet (10 mg, tid)2 monthsAE, BP
Peng et al. [30]30/3034/26WHO-ISHNGMH-1999QDD (1 dose/d)Losartan potassium tablet (50 mg, qd)2 monthsBP, ISI, INS
Song [31]36/3642/30WHO-ISHNGMH-1999Modified QDD (1 dose/d) + CAmlodipine besylate tablet (5 mg, qd)1 monthBP, CE, TCMSS, QL
Sun et al. [32]32/3126/37WHO-ISHNGMH-1999QDD (1.5 g, tid) + CTelmisartan tablet (40 mg, qd)1 monthAE
Wang [33]60/3048/42WHO-ISHNGMH-1999Modified QDD (1 dose/d) + CIrbesartan tablet (150 mg, qd)2 monthsBP, mA1b β2-MG, NAG
Wang et al. [34]40/4041/39DCPTHCQDD (9 g, bid) + CEnalapril maleate and folic acid tablet (0.8 mg, qd)1 monthAE, 24 h ABP
Yang and He [35]40/4046/34DCPTHCModified QDD (1 dose/d) + CEnalapril maleate capsules (5 mg, bid)3 monthsAE
Yu [36]50/5068/32DCPTHCQDD (1 dose/d) + CConventional antihypertensive drugs (ACEI, ARB, CCB, and diuretic)1 monthAE, Ang II, HsCRP
Zhang [37]34/3430/32WHO-ISHNGMH-1999QDD (1 dose/d) + CAmlodipine besylate tablet (5 mg, qd)1 monthAE, BP
Zhu [38]46/4649/43DCPTHCQDD (9 g, bid) + CNifedipine controlled release tablet (30 mg, qd)2 monthsAE, BP

Abbreviations. ABP: ambulatory blood pressure; ACEI: angiotensin-converting enzyme inhibitors; AE: antihypertensive effect; Ang II: angiotensin II; ARB: angiotensin receptor blockers; BP: blood pressure; β2-MG: β2-microglobulin; CADLI: conventional antihypertensive drugs and lifestyle interventions; CCB: calcium channel blocker; CE: clinical effects; DCPTHC: diagnostic criteria for the prevention and treatment of hypertension in China; ET: endothelin; GDTCDIMCM: guide to diagnosis and treatment of common diseases in internal medicine of Chinese medicine; HsCRP: high-sensitivity C-reactive protein; INS: insulin; ISI: insulin sensitivity index; NAG: N-acetyl-β-glucosidase; NR: not reported; QDD: Qiju Dihuang decoction; QL: quality of life; TCMSS: TCM syndrome score; WHO-ISH GMH: World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension.