Antimalarial Activity of Crude Extract and Solvent Fractions of the Leaves of Bersama abyssinica Fresen. (Melianthaceae) against Plasmodium berghei Infection in Swiss Albino Mice

Table 2

Effect of B. abyssinica crude extract and solvent fractions on the percentage parasitemia and survival time of P. berghei-infected mice in the 4-day suppressive test.

Group	% parasitemia (±SEM)	% suppression	MST (days) (±SEM)
DW 10 ml/kg	33.57 ± 1.99	0.00	6.17 ± 0.40
BA 100 mg/kg	21.17 ± 2.25	36.94^a3,b3	8.67 ± 0.42^b3
BA 200 mg/kg	20.18 ± 2.23	39.89^a3,b3	10.50 ± 0.76^a3,b3
BA 400 mg/kg	16.95 ± 1.52	49.51^a3,b3	13.83 ± 1.05^a3,b3,c3,d1
CQ 25 mg/kg	0.00 ± 0.00	100.00^a3	30.00 ± 0.00^a3
DW 10 ml/kg	32.66 ± 2.59	0.00	6.33 ± 0.62
AQ 100 mg/kg	21.38 ± 3.67	34.54^a1,b3	9.33 ± 1.30^b3
AQ 200 mg/kg	19.67 ± 1.08	39.78^a2,b3	10.50 ± 0.50^a1,b3
AQ 400 mg/kg	17.08 ± 2.26	47.69^a3,b3	13.60 ± 1.29^a3,b3,e1
EA 100 mg/kg	20.42 ± 3.12	37.48^a2,b3	8.83 ± 1.40^b3
EA 200 mg/kg	20.32 ± 2.13	37.78^a2,b3	9.17 ± 1.30^b3
EA 400 mg/kg	18.98 ± 0.39	41.89^a2,b3	12.00 ± 1.77^a1,b3
CH 100 mg/kg	23.50 ± 2.13	28.05^a1b3	8.17 ± 1.38^b3
CH 200 mg/kg	22.48 ± 1.90	31.17^a1b3	8.33 ± 0.95^b3
CH 400 mg/kg	20.18 ± 2.37	38.21^a2,b3	9.33 ± 1.67^b3
CQ 25 mg/kg	0.00 ± 0.00	100.00^a3	30.00 ± 0.00^a3

Data are expressed as mean ± SEM; n = 6, a = compared to DW, b = compared to CQ25 mg/kg, c = compared to BA 100 mg/kg, d = compared to BA 200 mg/kg, e = compared to AQ 100 mg/kg, 1 = , 2 = , 3 = ,  = negative and positive controls used for crude extract in the 4-day suppressive test, DW = distilled water, BA = B. abyssinica crude extract, EA = ethyl acetate fraction, CH = Chloroform fraction, AQ = aqueous fraction, CQ = chloroquine, SEM = standard error of mean, and MST = mean survival time.