Antimalarial Activity of Crude Extract and Solvent Fractions of the Leaves of Bersama abyssinica Fresen. (Melianthaceae) against Plasmodium berghei Infection in Swiss Albino Mice

Table 4

Effect of B. abyssinica crude extract and aqueous fraction on percentage parasitemia, and survival time of P. berghei-infected mice in Rane’s test.

Group	% parasitemia (±SEM)					% suppression	MST (days)
	D3	D4	D5	D6	D7
DW 10 ml/kg	21.63 ± 0.33	23.72 ± 0.68	25.27 ± 1.61	27.12 ± 0.78	29.68 ± 0.82	0.00	8.17 ± 0.48
BA 100 mg/kg	24.01 ± 0.48	24.30 ± 0.70	22.67 ± 0.92^b3	21.57 ± 1.64^b3	19.95 ± 1.42^a3,b3	34.37^a3,b3	13.29 ± 1.41^b3
BA 200 mg/kg	24.92 ± 0.83	24.07 ± 1.00	23.42 ± 1.36^b3	22.05 ± 2.91^b3	16.86 ± 1.08^a3,b3	43.19^a3,b3	14.50 ± 1.82^a2,b3
BA 400 mg/kg	25.05 ± 0.75	24.13 ± 0.76	21.87 ± 0.59^b3	19.75 ± 0.99^b3	12.48 ± 0.77^a3,b3,c3,d1	57.94^a3,b3,c3,d1	16.67 ± 0.49^a3,b3
AQ 100 mg/kg	24.88 ± 0.62	26.06 ± 0.65^b3	24.78 ± 0.90^b3	22.12 ± 0.89^b3	19.87 ± 0.56^a3,b3	31.40^a3,b3	11.60 ± 1.44^b3
AQ 200 mg/kg	24.73 ± 0.97	24.67 ± 0.97^b1	22.12 ± 0.64^b3	21.60 ± 1.34^b3	17.58 ± 1.44^a3,b3	40.77^a3,b3	13.83 ± 1.60^a1,b3
AQ 400 mg/kg	25.18 ± 0.80	24.03 ± 0.91^b1	22.87 ± 1.22^b3	20.92 ± 1.59^b3	14.36 ± 1.23^a3,b3,e2	51.62^a3,b3,e2	15.17 ± 1.87^a2,b3
CQ 25 mg/kg	22.68 ± 0.78	20.47 ± 1.07^a1	13.72 ± 1.51^a3	5.28 ± 2.42^a3	0.00 ± 0.00^a3	100.00^a3	30.00 ± 0.00^a3

Data are expressed as mean ± SEM; n = 6, a = compared to DW, b = compared to CQ 25 mg/kg, c = compared to BA 100 mg/kg, d = compared to BA 200 mg/kg, e = compared to AQ 100 mg/kg, 1 = , 2 = , 3 = , DW = distilled water, BA = Bersama abyssinica crude extract, AQ = aqueous fraction, CQ = chloroquine, SEM = standard error of mean, MST = mean survival time, D3 = day 3, D4 = day 4, D5 = day 5, D6 = day 6, and D7 = day 7.