Evaluation of Subchronic Toxicity and Genotoxicity of Ethanolic Extract of Aster glehni Leaves and Stems

Table 8

Observations of micronucleus and PCE:RBC ratio.

Test article	Dose (mg/kg/day)	Animals per dose	MNPCE^a (mean ± SD)	PCE:RBC ratio (mean ± SD)	% control
EAG	0	6	1.33 ± 1.03	0.57 ± 0.01	100
	500	5^b	1.20 ± 0.84	0.58 ± 0.02	101
	1,000	6	1.00 ± 1.10	0.57 ± 0.02	100
	2,000	6	1.50 ± 1.38	0.57 ± 0.01	99
CPA	70	6	110.50 ± 29.71	0.39 ± 0.02^##	69

Significant difference at levels compared with the negative control by the Mann–Whitney. ^##Significant difference at levels compared with the control by Student’s t-test. ^aRatio of MNPCE with 4,000 PCE, ^bOne of the mice was died. PCE, polychromatic erythrocyte; RBC, red blood cells (polychromatic erythrocyte + normochromatic erythrocyte); MNPCE, micronucleated polychromatic erythrocyte; and CPA, cyclophosphamide monohydrate (positive control).