Research Article
Hypoxia Upregulates NOTCH3 Signaling Pathway to Promote Endothelial-Mesenchymal Transition in Pulmonary Artery Endothelial Cells
Figure 5
miR-7-5p regulates NOTCH3 expression. (a) Map of miR-7-5p and NOTCH3 binding sites. (b) Double luciferase reporter assay. (c) miRNA pull-down experiment. (d) When miR-7-5p mimics were added to pulmonary artery endothelial cells, NOTCH3 content decreased. With the addition of miR-7-5p inhibitor, NOTCH3 levels increased. , one-way ANOVA. All data are presented as the mean ± SD for biological triplicate experiments. All data are presented as the mean ± SD for biological triplicate experiments.
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