The Effect of Terpenoid Natural Chinese Medicine Molecular Compound on Lung Cancer Treatment

Table 4

The molecular mechanism of terpenoid natural Chinese medicine small molecules to intervene in tumor cell autophagy in the treatment of lung cancer.

Terpenoid natural TCM small molecules	Experimental model	Dose/concentration	Mechanism of action	Ref.
Andrographolide (Andro)	A549 and Lewis lung cancer (LLC) cells	Andro (0, 7.5, 15, or μM) for 0, 6, 12, or 24 h	Suppressed autophagy;	[49]
			Enhanced cisplatin-mediated apoptosis;
Andrographolide (Andro)	A549 NSCLC cells	Andro (0, 7.5, 15, or μM) for 0, 6, 12, or 24 h	Promoted the activation of the Akt/mTOR signaling by downregulating PTEN and suppressed autophagy;	[50]
			Resensitized the resistant cells to cisplatin-mediated apoptosis;
Glycyrrhetinic acid (GA)	A549 and NCI-H1299 cells	GA (0, 40, and 60 µM) for 24 h	Induced cytoprotective autophagy;	[52]
			Activated the IRE1α-JNK/c-Jun pathway;
Hederagenin	NCI-H1299 and NCI-H1975 cells	Hederagenin (0, 25, 50, and 75 µM) for 0, 2, 6, 12, or 24 h	Induced the increased autophagosomes;	[53]
			Upregulation of LC3-II and p62;
			Indicated the impairment of autophagic flux