Zanthoxylum zanthoxyloides Alkaloidal Extract Improves CCl₄-Induced Hepatocellular Carcinoma-Like Phenotypes in Rats

Table 4

Effect of ZZAE on tumor incidence.

Treatment groups	^αTumor incidence
Control	0 to 5 ± 0.0
Model	˃15 ± 3.5^#
^aTween20	˃15 ± 2.8
Carvedilol (6.25 mg/kg)	10 to 15 ± 2.8
ZZAE (mg/kg)
50	10 to 15 ± 2.3
100	6 to 10 ± 0.8
200	6 to 10 ± 1.7

Each value is the mean ± SD, n = 4. (control versus model group); (treatments versus model group); ZZAE: Zanthoxylum zanthoxyloides alkaloidal extract; ^αdetermined by finding the average number of tumors counted by three independent researchers for each treatment group; ^avehicle for dissolution of ZZAE, 1 ml/rat.