Zanthoxylum zanthoxyloides Alkaloidal Extract Improves CCl₄-Induced Hepatocellular Carcinoma-Like Phenotypes in Rats

Table 5

Effect of ZZAE preexposure on CCl₄/olive oil-induced HCC.

Treatment groups	Change in mean body weight (g)	Change in mean liver weight (g)	Tumor multiplicity	Survival rate (%)
Control	91.60 ± 9.002	6.967 ± 0.412	0 to 5 ± 0.0	100
Model^a	28.92 ± 8.357^#	13.89 ± 1.759^#	˃15 ± 3.5^#	50
ZZAE only	83.065 ± 8.261	7.11 ± 0.481	0 to 5 ± 0.0	100
ZZAE^b	73.299 ± 1.567	9.453 ± 0.717	0 to 5 ± 0.0	100

^aReceived CCl₄-reconstituted in olive oil (1 : 1 v/v) (2 ml/kg ip twice a week for 16 weeks); ^breceived ZZAE (100 mg/kg po) before CCl₄/olive oil (1 : 1 v/v; 2 ml/kg ip; twice a week for 16 weeks); (control versus model group); (model versus other treatment groups) (ZZAE only and prophylactic ZZAE). ZZAE: Zanthoxylum zanthoxyloides alkaloidal extract.