Methanolic Extract of Myrsine africana Leaf Ameliorates Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Albino Mice

Table 4

Effect of M. africana methanolic leaf extract on oral glucose tolerance in normal mice.

Group	Fasting blood glucose level (mg/kg)
	0 min	30 min	60 min	120 min
NS 10 ml/kg	84.8 ± 3.8	206.6 ± 10.8 ^βG	160.6 ± 10.1 ^πG	96.1 ± 3.6 ^πG
MA 250 mg/kg	85.3 ± 3.9	204 ± 12.8 ^βG	146 ± 7.6 ^πG	98.8 ± 4.2 ^πG
MA 500 mg/kg	83.3 ± 4.7	208 ± 7.5 ^βG	141.6 ± 11.6 ^πG aF	106.3 ± 14 ^πG
MA 1000 mg/kg	83 ± 5.5	203.1 ± 9.6 ^βG	132 ± 6.6 ^πG aG	98.5 ± 5.2 ^πG
GLC 5 mg/kg	83.5 ± 4.3	206.3 ± 14.7 ^βG	85.3 ± 4.7 ^πG aG bG cG dG	75.3 ± 4.6 ^πG aF bG cG dG

Values are expressed as mean ± SD; n = 6; time refers to the time after oral glucose administration; ^a compared with the negative control, ^b compared with MA 250 mg/kg, ^c compared with MA 500 mg/kg, ^d compared with MA 1000 mg/kg, ^β compared with baseline blood glucose level, and ^π compared with the blood glucose level at 30 minutes; ^F, ^G; MA, Myrsine africana leaf extract; NS, normal saline; GLC, glibenclamide.