The Absorption, Distribution, and Excretion of 18 Elements of Tibetan Medicine Qishiwei Zhenzhu Pills in Rats with Cerebral Ischemia

Table 2

Changes in the contents of 18 elements in rats with cerebral ischemia (n = 6, μg/kg).

Element	Group	Absorption		Distribution			Excretion
		Hepatic venous blood	Abdominal aortic blood	Brain	Kidney	Liver	Urine	Hair	Feces
Li	Sham	1.799 ± 1.469	0.573 ± 0.240	0.021 ± 0.027	0.025 ± 0.035	—	0.298 ± 0.082	0.603 ± 0.128	0.9705 ± 0.03541
	QSW + MCAO	0.846 ± 0.119	0.827 ± 0.227	0.121 ± 0.053	0.261 ± 0.148	0.112 ± 0.113	2.921 ± 1.687	1.658 ± 0.417	22.74 ± 2.601
Be	Sham	0.041 ± 0.070	0.007 ± 0.008	0.021 ± 0.028	0.006 ± 0.008	0.006 ± 0.008	0.006 ± 0.007	0.002 ± 0.031	0.0447 ± 0.0216
	QSW + MCAO	0.015 ± 0.018	0.002 ± 0.006	—	0.002 ± 0.004	0.026 ± 0.058	0.005 ± 0.007	105.5 ± 211.1	87.93 ± 0.660
Sc	Sham	0.018 ± 0.024	0.002 ± 0.002	0.016 ± 0.013	0.002 ± 0.002	0.021 ± 0.028	0.001 ± 0.002	0.019 ± 0.007	0.0434 ± 0.0171
	QSW + MCAO	0.001 ± 0.001	0.001 ± 0.001	0.006 ± 0.005	0.008 ± 0.006	0.012 ± 0.007	0.004 ± 0.004	40.63 ± 81.18	95.76 ± 14.48
V	Sham	0.430 ± 0.328	0.029 ± 0.005	0.441 ± 0.072	0.736 ± 0.486	0.845 ± 0.664	0.023 ± 0.004	0.319 ± 0.033	11.28 ± 0.532
	QSW + MCAO	0.070 ± 0.087	0.045 ± 0.011	0.132 ± 0.015	1.057 ± 0.341	0.524 ± 0.199	0.068 ± 0.033	11.16 ± 21.32	35.49 ± 23.53
Cr	Sham	9.508 ± 6.316	7.412 ± 1.188	192.2 ± 26.37	9.153 ± 0.409	25.71 ± 18.07	6.913 ± 0.679	21.61 ± 1.308	0.912 ± 0.6191
	QSW + MCAO	11.09 ± 0.701	9.344 ± 0.713	9.889 ± 1.242	17.99 ± 16.83	36.01 ± 19.77	7.268 ± 0.506	25.31 ± 21.61	12.740 ± 8.081
Mn	Sham	1.166 ± 1.643	0.027 ± 0.055	12.38 ± 3.375	30.41 ± 12.66	29.13 ± 0.699	0.038 ± 0.075	7.336 ± 0.793	330.8 ± 167.5
	QSW + MCAO	2.246 ± 5.481	0.009 ± 0.022	10.08 ± 1.656	262.3 ± 52.30	80.75 ± 10.24	0.241 ± 0.248	40.16 ± 30.79	50480 ± 27940
Co	Sham	0.044 ± 0.023	0.013 ± 0.006	0.493 ± 0.272	1.481 ± 1.650	1.395 ± 1.362	0.135 ± 0.177	0.115 ± 0.016	0.2862 ± 0.1663
	QSW + MCAO	0.047 ± 0.053	0.026 ± 0.004	0.089 ± 0.011	1.783 ± 0.303	0.589 ± 0.116	0.139 ± 0.074	0.656 ± 0.748	42.86 ± 9.576
Ni	Sham	41.84 ± 21.08	31.91 ± 4.188	977.7 ± 616.2	36.22 ± 0.577	38.97 ± 0.064	28.98 ± 2.942	77.52 ± 12.03	30.60 ± 13.27
	QSW + MCAO	46.04 ± 2.302	37.96 ± 3.100	37.06 ± 4.362	36.94 ± 1.428	36.74 ± 1.222	28.79 ± 2.422	38.78 ± 0.989	1460 ± 1977
Cu	Sham	66.99 ± 47.98	54.53 ± 48.46	147.2 ± 17.60	196.4 ± 2.363	206.3 ± 24.72	59.11 ± 39.59	147.6 ± 5.267	12.68 ± 62.45
	QSW + MCAO	41.11 ± 41.22	46.93 ± 44.93	140.3 ± 9.885	255.4 ± 48.35	220.1 ± 13.79	30.79 ± 44.10	269.9 ± 105.1	2325 ± 191.3
As	Sham	368.9 ± 269.3	209.02 ± 74.28	3.215 ± 1.613	19.27 ± 6.584	19.73 ± 4.745	1.541 ± 0.038	1.792 ± 0.352	0.2964 ± 0.1596
	QSW + MCAO	101.2 ± 3.592	157.4 ± 25.59	2.042 ± 0.275	19.59 ± 4.862	23.95 ± 5.165	4.224 ± 0.464	55.86 ± 104.4	81.92 ± 9.358
Sr	Sham	3.028 ± 4.483	0.026 ± 0.052	0.658 ± 0.299	0.262 ± 0.371	0.598 ± 0.042	0.581 ± 0.082	2.085 ± 0.1211	18.63 ± 7.826
	QSW + MCAO	1.156 ± 2.427	0.451 ± 0.132	0.516 ± 0.144	1.055 ± 0.492	0.265 ± 0.494	5.612 ± 3.481	6.876 ± 5.843	3091 ± 1423
Ag	Sham	0.116 ± 0.053	0.011 ± 0.014	0.854 ± 1.242	0.016 ± 0.001	0.091 ± 0.079	—	0.632 ± 0.979	0.1119 ± 0.01198
	QSW + MCAO	0.130 ± 0.150	0.020 ± 0.023	0.142 ± 0.079	0.195 ± 0.097	0.147 ± 0.091	0.058 ± 0.036	5.781 ± 10.01	151.30 ± 69.56
Cd	Sham	0.030 ± 0.034	—	0.064 ± 0.031	0.229 ± 0.086	0.232 ± 0.095	—	0.025 ± 0.008	0.0107 ± 0.0559
	QSW + MCAO	0.022 ± 0.038	0.001 ± 0.002	0.003 ± 0.004	0.153 ± 0.088	0.152 ± 0.076	0.005 ± 0.004	18.79 ± 37.49	2063 ± 203.9
Cs	Sham	0.119 ± 0.076	0.051 ± 0.019	0.269 ± 0.047	0.435 ± 0.007	0.509 ± 0.105	0.069 ± 0.001	0.056 ± 0.005	0.0156 ± 0.0056
	QSW + MCAO	0.054 ± 0.010	0.078 ± 0.009	0.296 ± 0.068	0.908 ± 0.167	0.782 ± 0.097	0.233 ± 0.114	15.02 ± 29.69	242.5 ± 113.5
Ba	Sham	3.597 ± 3.848	1.477 ± 1.124	0.512 ± 0.465	0.235 ± 0.332	0.453 ± 0.634	—	2.103 ± 0.291	4.731 ± 1.736
	QSW + MCAO	2.816 ± 5.429	0.352 ± 0.233	0.580 ± 1.037	0.662 ± 0.559	0.257 ± 0.500	—	6.439 ± 6.517	10360 ± 8227
Pb	Sham	0.925 ± 1.059	—	—	—	0.161 ± 0.028	—	0.830 ± 0.362	0.2564 ± 0.1205
	QSW + MCAO	0.477 ± 1.168	—	0.122 ± 0.176	1.216 ± 0.951	2.672 ± 2.554	0.204 ± 0.378	6.747 ± 3.947	198.40 ± 154.50
Au	Sham	0.024 ± 0.027	—	0.003 ± 0.006	0.013 ± 0.018	0.007 ± 0.009	—	—	0.0131 ± 0.0204
	QSW + MCAO	0.010 ± 0.017	0.004 ± 0.006	0.020 ± 0.029	0.351 ± 0.372	0.179 ± 0.207	0.022 ± 0.043	3.171 ± 3.106	12.01 ± 23.46
Hg	Sham	0.630 ± 0.394	0.429 ± 0.174	0.283 ± 0.099	0.468 ± 0.423	0.592 ± 0.445	0.050 ± 0.012	0.624 ± 0.103	0.0117 ± 0.005
	QSW + MCAO	0.460 ± 0.226	0.359 ± 0.032	0.358 ± 0.112	2.998 ± 1.231	0.606 ± 0.083	0.794 ± 0.446	9.332 ± 2.793	118.50 ± 84.31

The symbol “—” means not detected or lower than the detection limit; compared with the Sham group, .