Hepatoprotective Effects of (−) Epicatechin in CCl₄-Induced Toxicity Model Are Mediated via Modulation of Oxidative Stress Markers in Rats

Figure 9

Effect of (−) epicatechin and silymarin on histopathological changes in CCl₄-induced toxicity study. The collagen components are stained blue, and the cytoplasm appears in varying degrees of red. GI: showing few amounts of collagen fibers around the portal area (PA), portal vein (PV), and bile duct (BD). GII: no change in collagen density. GIII: collagen is increased in the portal region forming bridges between the lobules (white arrows). High-power X400 showed dilated portal vein (PV) and marked fibrosis around bile duct (BD). GIV: moderate deposition in collagen in CV, PA, and PV areas. GV: mild collagen deposition.