TCM Regulates PI3K/Akt Signal Pathway to Intervene Atherosclerotic Cardiovascular Disease

Table 2

The mechanism of Chinese herbal compound influencing AS through PI3K/Akt signaling pathway.

Name	Mechanism	Model	Reference
Danhong injection	Improve blood lipid level, reduce AS index and plaque area, inhibit TC level, activate the PI3K/Akt insulin signaling pathway to prevent lipid accumulation in macrophages, and improve the prognosis of AS	ApoE^−/– mouse	[62]
Qishen capsules	Regulate blood lipids and inhibit the phosphorylation and overactivation of PI3K and Akt protein	ApoE^−/– mouse	[65]
Tongxinluo	Upregulate the expression of HIF in vascular endothelial cells through PI3K/Akt/HIF dependent signaling pathways and improve the ability of vascular endothelial cells to resist hypoxia injury	HUVECs	[70]
Buyang Huanwu decoction	Inhibit the expression of PI3K and p-Akt proteins activated by LPS stimulation and inhibit downstream inflammatory factors	Male rabbit	[64]
Danggui Buxue decoction	Regulate the activity of endothelial progenitor cells through PI3K/Ak t pathway, improve their functions, and repair vascular endothelium	Endothelial progenitor cells; New Zealand male rabbit	[71]