Research Article

Suppression of Inflammatory and Fibrotic Signals by Cinnamon (Cinnamomum cassia) and Cinnamaldehyde in Cyclophosphamide-Induced Overactive Bladder in Mice

Figure 7

Graphical illustration showing the key pathways regulated by CNP and CNA. CNP and CNA have a profound effect on the inhibition of cyclophosphamide- (CYP-) induced OAB bladder injury in inflammation and fibrosis pathways via inhibiting MIF/TLR4- and SCF/c-Kit-mediated signal transduction, which in turn suppresses pp65NFκB/CD11b and β-catenin/α-SMA upregulation, respectively.