Research Article

The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity

Table 1

The list of obesity-related SNPs checked in this study.

GenePhenotypeReference

ADRB2 rs1042713rs1042714Starch obesityV. Large, L. Hellstrom, S. Reynisdottir et al. “Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function,” J Clin Invest, vol. 100, no. 12, pp. 3005–3013.
J.A. Martínez, M.S. Corbalán, A. Sánchez-Villegas, L. Forga, A. Marti, and M.A. Martínez-González, “Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta-2 adrenoceptor polymorphism,” J Nutr, vol. 133, no. 8, pp. 2549–2554.

ADRB3 rs4994Visceral obesityH. Kim-Motoyama, K. Yasuda, T. Yamaguchi et al., “A mutation of the beta-3 adrenergic receptor is associated with visceral obesity but decreased serum triglyceride,” Diabetologia, vol. 40, no. 4, pp. 469–472.

GNB3 rs5443Metabolism obesityK.D. Ko, K.K. Kim, H.S. Suh, and I.C. Hwang, “Associations between the GNB3 C825 T polymorphism and obesity-related metabolic risk factors in Korean obese women,” J Endocrinol Invest, vol. 37, no. 11, pp. 1117–1120.

UCP1 rs1800592Stubborn obesityR.A. Busiello, S. Savarese, and A. Lombardi, “Mitochondrial uncoupling proteins and energy metabolism,” Front Physiol, vol. 6, p. 36.
M. Dhall, M.M. Chaturvedi, U. Rai, and S. Kapoor, “Sex-dependent effects of the UCP1 -3826 A/G polymorphism on obesity and blood pressure,” Ethn Dis, vol. 22, no. 2, pp. 181–184.

FTO rs9939609Energy intakeE. Karra, O.G. O'Daly, A.I. Choudhury et al. “A link between FTO, ghrelin, and impaired brain food-cue responsivity,” J Clin Invest, vol. 123, no. 8, pp. 3539–3551.
BMIM. Claussnitzer, S.N. Dankel, K.H. Kim et al., “FTO obesity variant circuitry and adipocyte browning in Humans,” N Engl J Med, vol. 373, no. 10, pp. 895–907.