Meta-Analysis of the Effect of Traditional Chinese Medicine Compounds Combined with Standard Western Medicine for the Treatment of Diabetes Mellitus Complicated by Coronary Heart Disease

Table 1

Basic characteristic of included studies.

Inclusion studies	Sample size		Male/female		Average age		Intervention measures		Treatment course	Outcome indicators
	T	C	T	C	T	C	T	C
Zhang 2020 [13]	50	50	24/26	26/24	66.14 ± 2.25	66.28 ± 2.33	Control group + tongxinluo capsule	Metformin	—	(1) (2) (5) (6) (7)
Zhang 2020 [14]	58	58	39/19	37/21	57.05 ± 10.94	56.46 ± 10.37	Control group + guilou xiebai banxia and huangqi xiaoke decoctions	Metformin hydrochloride sustained-release tablets + isosorbide mononitrate tablets	—	(2) (13)
Zhang 2020 [15]	52	52	30/22	28/24	51.6 ± 8.2	50.4 ± 9.5	Control group + danshen ligustrazine injection	Standard western medicine	2 weeks	(1) (7)
Zhang and Zhang 2020 [16]	48	48	30/18	33/15	60.21 ± 15.37	59.87 ± 14.65	Control group + tongxinluo capsule	Isosorbide mononitrate sustained-release tablets + aspirin enteric-coated tablets + metoprolol tartrate + valsartan capsules + atorvastatin	12 weeks	(7) (11)
Ye 2020 [17]	30	30	14/16	15/15	65.7 ± 8.9	65.2 ± 7.6	Control + buyang huanwu decoction	Calcium antagonists + anti-platelet drugs + β receptor blockers + nitrate drugs, lipid-regulating drugs + angiotensin converting enzyme inhibitors	3 months	(1) (5) (6) (7) (10)
Xing et al. 2019 [18]	100	100	45/55	42/58	53.01 ± 2.52	51.84 ± 3.15	Control group + tongxinluo, ganlu xiaoke capsule	Isosorbide dinitrate + aspirin enteric-coated tablets + atorvastatin	—	(4) (5) (6) (14)
Guan and Shang 2019 [19]	39	39	24/15	22/17	54.5 ± 2.9	54.8 ± 2.6	Standard western medicine + mai san	Standard western medicine + compound danshen drop pills	2 months	(1) (9) (12)
Liu et al. 2019 [20]	50	50	34/16	32/18	54.18 ± 8.46	53.66 ± 9.12	Control group + shenqi guilou xiebai banxia decoction	Metformin hydrochloride sustained-release tablets + isosorbide mononitrate tablets	45 days	(1) (7) (15)
Jiang 2019 [21]	35	35	18/17	19/16	57.2 ± 7.4	58.9 ± 8.2	Standard western medicine + phlegm and blood stasis decoction	Standard therapy + trimetazidine hydrochloride	4 weeks	(1) (2) (5) (6)
Zuo 2019 [22]	37	37	21/16	23/14	44.15 ± 3.17	43.93 ± 3.04	+ Shengmai San decoction	Danshen dropping pill + compound danshen dropping pill	2 months	(5) (6) (13)
Liu et al. 2019 [23]	54	54	28/26	29/25	67.03 ± 6.12	66.78 ± 5.81	Control group + musk yangxin san	Sodium trimetazidine + isosorbide mononitrate tablets + aspirin enteric-coated tablets	3 month	(1) (5) (6) (7) (8) (16)
Sun et al. 2018 [24]	40	40	21/19	22/18	53.4 ± 1.5	52.5 ± 1.3	Control group + deconstruction of phlegm and removing blood stasis	Standard western medicine	1 month	(1) (5) (6) (17)
Liu et al. 2018 [25]	35	35	21/14	19/16	46.35 ± 2.36	45.32 ± 2.12	Control group + yiqi shufeng tongluo tang	Atorvastatin	—	(1) (3) (13)
Deng 2018 [26]	40	40	21/19	23/17	61.3 ± 5.1	60.1 ± 5.4	Antidiabetic drugs/insulin + long-acting analgesic drugs + ziyin huoxue decoction	Antidiabetic drugs/insulin + long-lasting analgesic drugs + compound danshen dropping pills	1 month	(1) (4) (5) (6) (7) (14)
Zhang 2017 [27]	42	41	23/19	24/17	61.23 ± 12.51	61.42 ± 12.38	Control group + danhong injection	Standard western medicine	2 weeks	(1) (2) (3) (5)
Yan et al. 2017 [28]	35	35	19/16	20/15	41.1 ± 12.9	42.8 ± 13.2	Control group + yiqihua turbid capsule	Antidiabetic drugs, anti-platelet, β receptor blockers, statins	3 months	(1) (2) (5) (6) (13)
Sui 2016 [29]	200	200	100/100	98/102	57.49 ± 1.26	57.5 ± 1.25	Antidiabetic drugs/insulin + long-acting analgesic drugs + ziyin huoxue decoction	Antidiabetic drugs/insulin + long-lasting analgesic drugs + danshen dropping pills	1 months	(5) (6) (7)
Tang 2016 [30]	55	55	30/25	32/23	56.15 ± 1.54	57.1 ± 1.36	Control group + ziyin huoxue decoction.	Antidiabetic drugs + insulin + long-lasting analgesic drugs	1 month	(5) (6) (7)
Li and Shang 2015 [31]	19	22	7/12	9/13	59.86 ± 7.44	61.21 ± 7.38	Control group + qishen yiqi dropping pills	Standard western medicine	8 weeks	(1) (2) (5) (6) (7)
He 2013 [32]	40	63	—	—	—	—	Antidiabetic drugs/insulin + long-acting analgesic drugs + ziyin huoxue decoction	Antidiabetic drugs/insulin + long-acting analgesic drugs + guanxin danshen dropping pills	1 month	(1) (4) (5) (6) (7)
Liu 2012 [33]	68	62	46/22	42/20			Conventional treatment + trimetazidine hydrochloride	Standard treatment + phlegm-dispelling and stasis removing decoction		(1) (2) (3) (4)
Li and Yang 2009 [34]	36	36	14/22	11/25	59.5 ± 8.96	57.62 ± 8.76	Antidiabetic drugs/insulin + long-acting analgesic drugs + ziyin huoxue decoction	Antidiabetic drugs/insulin + long-acting analgesic drugs + compound danshen dropping pills	4 weeks	(1) (4) (5) (6) (7)
Ma 2009 [35]	30	30	15/15	15/15	—	—	Control group + yiqi tongluo capsule	Antidiabetic drugs/insulin + isosorbide dinitrate tablets	1 month	(1) (4) (5) (6) (13) (14)

T, observation group; C, control group; (1), total effective rate; (2), electrocardiogram effective rate; (3), adverse reaction; (4), angina pectoris attack times; (5), blood glucose; (6), 2-hour plasma glucose (2hPG); (7), blood lipid; (8), hemorheological index; (9), reactive protein; (10), interleukin 6; (11), glycosylated hemoglobin; (12), β2-microglobulin; (13), TCM syndrome score; (14), angina pectoris pain duration; (15), vascular endothelial function; (16), coagulation function; (17), heart rate.