Research Article

Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Table 3

Identification of significant differential metabolites in tongue coating by comparison of the damp phlegm pattern group and healthy control group.

Metabolite nameRT (min)m/zMean damp phlegm patternMean healthy controlVIPLog fold changeDetection method

Lipids and lipid-like molecules
Foeniculoside VII71.4543490.5160.057<0.011.4113.166LC+
Glycerol tripropanoate61.3452611.1520.109<0.011.4173.400LC+
Solavetivone115.3092190.1980.014<0.011.0813.785LC+
Patchoulenone61.0622193.2060.278<0.011.2383.528LC+
LysoPE(14 : 1(9Z)/0 : 0)194.5634241.6790.000<0.011.34014.686LC+
Gibberellin A7971.8563650.0590.010<0.011.3502.615LC+
Oleic acid33.2902830.2460.086<0.011.1961.518LC+
Dexamethasone77.2023930.2410.030<0.011.3433.000LC+
Leukotriene D470.9254973.8671.431<0.011.1381.434LC+
Gynosaponin S73.6809480.0830.013<0.011.2512.655LC+
3-O-methylniveusin A77.4454090.0400.004<0.011.2873.346LC+
Hoduloside VII248.6519320.9170.103<0.011.4073.153LC+
L-Acetylcarnitine328.1452040.0390.025<0.011.0920.629LC+
Fucoxanthin259.1396590.0810.008<0.011.4083.303LC+
Citronellyl beta-sophoroside91.0994810.0810.009<0.011.3343.169LC+
N-Cyclopropyl-trans-2-cis-6-nonadienamide46.0681940.1750.013<0.011.3063.748LC+
3-Hydroxyisovalerylcarnitine57.6882620.1070.010<0.011.4053.358LC+
Lyciumoside III142.8036490.0260.002<0.011.3593.643LC+
Fencamfamine34.4392160.2750.113<0.011.0991.291LC+
(3beta,5alpha,9alpha,22E,24R)-5,9-epidioxy-3-hydroxyergosta-7,22-dien-6-one246.0644430.7030.060<0.011.3743.547LC+
Herculin194.3012520.7530.416<0.011.1750.858LC+
Eicosadienoic acid33.3113090.8010.094<0.011.4133.096LC+
3beta-acetoxy-11alpha-methoxy-12-ursen-28-oic acid193.6975430.0790.009<0.011.2173.211LC+
Antibiotic X 14889C257.7596150.0860.009<0.011.4093.311LC+
2-Ethyl-2-hydroxybutyric acid58.6561330.7100.056<0.011.3603.670LC+
Alliospiroside C120.6427250.7990.113<0.011.3862.821LC+
(22E, 24x)-ergosta-4,6,8,22-tetraen-3-one38.0563930.5880.196<0.011.2731.585LC+
3-Methoxy-4-hydroxyphenylglycol glucuronide293.1934190.4040.045<0.011.4113.159LC+
Physalin O314.5125290.1280.013<0.011.3403.291LC+
Fevicordin B 2-gentiobioside185.5658690.2740.018<0.011.3533.943LC+
Desglucocoroloside220.2655050.0310.008<0.011.0742.006LC+
3-Methylglutarylcarnitine84.8512900.2700.023<0.011.4103.552LC+
Smilanippin A113.7807250.6020.047<0.011.4183.682LC+
PS(16 : 1(9Z)/18 : 4(6Z,9Z,12Z,15Z))207.2227540.0750.007<0.011.4073.514LC+
CPA(18 : 0/0 : 0)278.9184210.2080.020<0.011.4163.379LC+
Hericenone E243.8625950.3520.032<0.011.4153.474LC+
Glycerol tributanoate125.3673030.1790.009<0.011.4234.287LC+
Fasciculic acid C116.1867100.4440.044<0.011.3543.324LC+
Hebevinoside I38.3828090.1000.008<0.011.3993.557LC+
Phosphatidylethanolamine165.6957840.1210.008<0.011.3403.899LC+
Lycoperoside D154.4077400.5480.043<0.011.4193.659LC+
Chondrillasterol 3-[glucosyl-(1->4)-glucoside]97.6207370.6740.131<0.011.3382.358LC+
PA(18 : 4(6Z,9Z,12Z,15Z)/14 : 1(9z))246.7996390.1780.029<0.011.3262.599LC+
(24E)-3alpha,15alpha-diacetoxy-23-oxo-7,9(11),24-lanostatrien-26-oic acid188.6465690.3590.058<0.011.2362.639LC+
Physapruin B227.1036030.0950.021<0.011.1462.200LC+
PG(18 : 1(11Z)/22 : 5(4Z,7Z,10Z,13Z,16Z))230.2378240.7070.015<0.011.4305.573LC+
Trihexosylceramide (d18 : 1/12 : 0)257.5839690.3620.090<0.011.3092.008LC+
Traumatic acid281.3452290.5070.047<0.011.3643.440LC+
Lactosylceramide31.38810030.0044.397<0.011.316-10.250LC+
Sphinganine 1-phosphate51.5803820.1490.008<0.011.4294.202LC+
Budesonide167.5554310.8800.012<0.011.2286.183LC+
3-Benzoyloxy-11-oxo-12-ursen-28-oic acid34.3775752.1360.156<0.011.4223.776LC+
3a,7b,12a-Trihydroxyoxocholanyl-Glycine243.2384660.6480.047<0.011.0513.788LC+
Momordicoside K69.7666490.6910.161<0.011.3402.100LC+
PI(22 : 5(4Z,7Z,10Z,13Z,16Z)/16 : 0)244.5078860.1410.010<0.011.3383.842LC+
Vinaginsenoside R384.8539320.4860.035<0.011.4183.811LC+
PA(18 : 4(6Z,9Z,12Z,15Z)/18 : 4(6Z,9Z,12Z,15Z))144.6196890.0180.001<0.011.1853.617LC+
Dodecanoic acid49.52219910.4805.041<0.011.4671.056LC−
Hydroxyisocaproic acid251.7721313.1680.297<0.011.4283.414LC−
5,15-DiHETE108.6973350.1190.002<0.011.7415.644LC−
Adipic acid394.0381457.0341.213<0.011.5842.536LC−
13S-hydroxyoctadecadienoic acid50.0072950.6420.230<0.011.5851.481LC−
Prostaglandin D246.5553511.2680.105<0.011.1903.601LC−
9,10-DHOME81.2763130.1200.008<0.011.6073.946LC−
Azelaic acid359.7131870.1880.010<0.011.7874.170LC−
(10E,12Z)-(9S)-9-hydroperoxyoctadeca-10,12-dienoic acid60.7153110.1200.005<0.011.7034.569LC−-
6beta-hydroxyasiatic acid51.6045030.1350.012<0.011.7623.463LC−
Fasciculol C257.9435530.0060.001<0.011.3543.406LC−
Traumatic acid139.9322270.2300.022<0.011.6083.369LC−

Organic acids and derivatives
Pantothenic acid11.3581030.0140.002<0.011.1182.536GC
Bortezomib285.0564070.0770.006<0.011.4143.773LC+
Ustiloxin D287.0914950.0410.003<0.011.4123.737LC+
N,N-Dimethylformamide300.102740.1430.085<0.011.0350.743LC+
Oseltamivir314.5763130.1430.015<0.011.3223.249LC+
Arginyl-arginine296.6313312.1220.170<0.011.4213.643LC+
Arginyl-histidine166.7233120.4120.030<0.011.4193.784LC+
Dihydro-3-(2-octenyl)-2,5-furandione281.3912110.1310.017<0.011.2432.963LC+
N-Acetylleucine265.0671740.1400.010<0.011.3523.829LC+
L-cis-3-amino-2-pyrrolidinecarboxylic acid75.7821310.0270.002<0.011.3403.693LC+
L-Homocysteic acid124.1201820.1270.008<0.011.7863.970LC−
3-Hydroxycapric acid83.3061870.2410.088<0.011.4501.448LC−

Organic oxygen compounds
Leonuriside A372.0373330.0120.001<0.011.4294.365LC+
Kanamycin205.4474850.0360.004<0.011.3723.253LC+
Guanadrel sulfate79.8402143.9120.331<0.011.4183.562LC+
Trimethylaminoacetone206.2351160.1130.007<0.011.2284.102LC+
4-Ipomeanol72.9411670.3110.024<0.011.0043.699LC−

Benzenoids
Dictagymnin60.9982030.0680.005<0.011.0813.698LC+
4’-hydroxyfenoprofen glucuronide281.4544350.0890.007<0.011.4013.626LC+
Methoxamine410.7262120.0370.004<0.011.3023.038LC+
N-undecylbenzenesulfonic acid103.0103130.1870.092<0.011.1331.031LC+
Salmeterol57.0914160.4680.044<0.011.4193.415LC+
Esmolol175.5132960.1680.015<0.011.3453.498LC+
(±)-2-(1-methylpropyl)-4,6-dinitrophenol31.3782392.8501.286<0.011.0731.148LC−

Organoheterocyclic compounds
Pirenzepine132.1483520.4330.047<0.011.4033.206LC+
Neferine264.6176250.8450.118<0.011.3902.841LC+
Pyrimidine112.505810.0970.008<0.011.4163.566LC+
5,6-Dihydroxyindole45.0661500.2560.031<0.011.2263.029LC+
2-Pyrrolidineacetic acid64.0581300.6840.340<0.011.1651.009LC+
Alpha-carboxy-delta-decalactone125.9592150.0850.004<0.011.4134.275LC+
I-Urobilin174.1135910.1020.006<0.011.4134.117LC+
4-Ethyl-5-methyl-2-(1-methylethyl)oxazole244.5321540.6570.081<0.011.2493.023LC+
Garcimangosone C282.0764130.8930.071<0.011.4053.654LC+
8-Hydroxycarteolol116.9083090.1640.018<0.011.4153.203LC+
3-Methyl-1-hydroxybutyl-ThPP281.4085110.0400.003<0.011.3943.675LC+
Azaspiracid 3109.9978280.0890.034<0.011.0001.385LC+
3’-N-acetyl-4'-O-(9-octadecenoyl)fusarochromanone328.7285990.0270.004<0.011.0802.884LC+

Organic nitrogen compounds
1-Butylamine268.8477411.9330.834<0.011.3603.839LC+
Nervonyl carnitine237.324102659.91766.315<0.011.3423.315LC+
Isobutylpropylamine231.6501160.4440.041<0.011.4173.420LC+
2-Diethylaminoethanol300.009118195.97613.198<0.011.4243.892LC+
Dipyridamole47.7612530.2980.016<0.011.4264.263LC+

Phenylpropanoids and polyketides
Kanzonol V244.5733770.0050.457<0.011.096−6.613LC+
Sofalcone285.8824510.0630.005<0.011.4153.788LC+
Kanzonol F247.9434210.0030.360<0.011.135-7.002LC+
Kanzonol I83.2714370.0600.000<0.011.0519.876LC+

Homogeneous nonmetal compounds
Phosphoric acid32.551990.6430.052<0.011.2463.632LC+

Organosulfur compounds
(±)-2-pentanethiol32.7691050.3970.080<0.011.0892.302LC+

Hydrocarbons
1-Methyl-1,3-cyclohexadiene32.571950.4770.093<0.011.1822.356LC+

Others
6-deoxyglucitol10.1731170.0060.001<0.012.2202.432GC
1,2,4-benzenetriol9.3441240.2130.015<0.012.2403.856GC
Isoxanthopterin12.0911000.0020.001<0.011.5981.130GC
Lactobionic acid 214.9321470.0320.013<0.011.3421.289GC
2,4-dichloro-1-(2-chloroethenyl)-benzene7.9251700.4760.034<0.012.3413.823GC
Asparagine dehydrated8.6281100.0110.002<0.012.2122.434GC
4-Hydroxybenzoate9.4231102.4580.161<0.012.3433.933GC
Conduritol-beta-expoxide11.5411030.1740.019<0.012.2313.190GC
Methylmaleic acid7.9231700.4770.034<0.012.3413.826GC
4-Methylcatechol7.9281700.4520.034<0.012.1483.749GC
Beta-mannosylglycerate12.2712040.0000.000<0.011.3500.739GC
Uridine minor13.3541450.0660.007<0.012.3183.263GC
(10S,11R)-pterosin C 4-glucoside282.23239716.0941.266<0.011.3313.669LC+
PC(P-18 : 1(9Z)/16 : 0)36.1737450.6930.070<0.011.4163.299LC+
LysoPC(18:1(9Z))210.7785440.0190.001<0.011.0044.867LC+
PC(P-16 : 0/18 : 4(6Z,9Z,12Z,15Z))153.4937390.0480.005<0.011.2003.387LC+

GC: GC-TOF-MS; LC+: UHPLC-QE-MS positive ion; LC−: UHPLC-QE-MS negative ion.