Sishen Pill Maintained Colonic Mucosal Barrier Integrity to Treat Ulcerative Colitis via Rho/ROCK Signaling Pathway

Figure 1

Therapeutic evaluation of SSP-treated chronic colitis in rats. (a) Schedule of Experimental protocol; (b) body weight change during SSP treatment every day; (c) body weight of rats; (d) clinical score; (e) typical images of intact colon and macroscopic view of opened colon; (f) CMDI; (g) colon length; (h) colon weight; (i) colon weight index. Data are presented as means ± SEM (n = 8). and ^∗∗P < 0.01 versus the normal group; versus the TNBS group. Typical histological images (J, K, L, M) stained with H&E, bar = 100 μm or 200 μm; (j) J1, J2: normal; (k) K1, K2: TNBS; (l) L1, L2 : TNBS + SSP; (m) M1, M2: TNBS + 5-ASA. (n) Microscopic score. (o) IL-1β. (p) TNF-α. Data are presented as means ± SEM (n = 8). versus the normal group; and versus the TNBS group.

(a)

(b)