Antidepressant and Anxiolytic Effects and Subacute Toxicity of the Aerial Parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in Murine Models

Table 5

Results from serum biochemical parameters analyses of the various groups.

Parameter	Control	PAE 100 mg/kg	PAE 300 (mg/kg)	PAE 1000 mg/kg
TBil (µmol/L)	8.17 ± 0.24	9.06 ± 0.70	8.69 ± 0.78	7.86 ± 0.44
Dbil (µmol/L)	3.62 ± 0.42	3.57 ± 0.24	3.78 ± 0.20	3.38 ± 0.19
TP (g/L)	70.48 ± 2.49	69.8 ± 1.29	73.40 ± 3.33	79.66 ± 4.65
ALB (g/L)	28.90 ± 0.74	29.1 ± 1.52	29.10 ± 2.01	30.70 ± 0.51
GLB (g/L)	39.50 ± 1.30	40.70 ± 2.00	44.33 ± 1.99	44.38 ± 1.54
A/G	0.65 ± 0.08	0.72 ± 0.06	0.65 ± 0.05	0.62 ± 0.08
ALT (U/L)	54.51 ± 4.60	59.49 ± 7.30	67.92 ± 6.32	71.08 ± 5.15
ALP (U/L)	79.56 ± 1.30	77.55 ± 4.75	75.53 ± 4.45	78.24 ± 3.23
AST (U/L)	95.02 ± 9.12	116.30 ± 16.08	113.40 ± 18.50	99.68 ± 8.79
GGT (U/L)	6.2 ± 0.58	7.67 ± 1.33	6.50 ± 1.56	7.60 ± 0.40
UREA (mmol/L)	6.96 ± 0.50	5.77 ± 0.66	7.28 ± 1.31	6.76 ± 0.89
CREAT(µmol/L)	145.00 ± 2.76	119.30 ± 10.93	130.10 ± 17.83	134.70 ± 4.39
UA (µmol/L)	33.66 ± 3.72	30.48 ± 2.40	27.33 ± 2.38	28.30 ± 3.60
GLU (µmol/L)	7.586 ± 0.88	11.04 ± 1.77	7.79 ± 1.11	11.20 ± 1.38
Ca (µmol/L)	2.54 ± 0.02	2.64 ± 0.08	2.69 ± 0.06	2.58 ± 0.01
LDL (µmol/L)	0.64 ± 0.08	0.72 ± 0.03	0.72 ± 0.07	0.64 ± 0.05
TG (µmol/L)	1.01 ± 0.12	0.69 ± 0.09	1.03 ± 0.19	0.84 ± 0.09
CHOL (µmol/L)	1.79 ± 1.00	1.58 ± 0.07	2.11 ± 0.14	1.82 ± 0.11
HDL C (µmol/L)	0.63 ± 0.05	0.56 ± 0.03	0.88 ± 0.03	0.75 ± 0.08

Results are presented as Mean ± SEM (n = 5): one-way analysis of variance of all the datasets revealed no statistical significance (). TBill: total bilirubin, DBill: direct bilirubin, TP: total proteins, ALB: albumin, GLB: globulins, ALT: alanine aminotransferase, ALP: alkaline phosphatase, AST: aspartate aminotransferase, CREAT: creatinine, UA: uric acid, GLU: glucose, and TG: triglycerides, CHOL: cholesterol, LDL: low-density lipoprotein, HDL C: high-density lipoprotein C, Ca: calcium, GGT: gamma GT, and A/G: albumin-to-globulins ratio.