Shikonin Attenuates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment by Inhibiting Apoptosis via PTEN/Akt/CREB/BDNF Signaling

<div>Nissl staining showing the effects of SK on neuronal morphology in hippocampal area CA1. Representative images of pyramidal neuron damage in the CA1 region. Scale bar = 20 <i>μ</i>m. Magnification: 400x. (a) Sham group; (b) vehicle group; (c) SK-L group; (d) SK-H group.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 2

Figure 2: Shikonin Attenuates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment by Inhibiting Apoptosis via PTEN/Akt/CREB/BDNF Signaling 