Network Pharmacology Prediction and Pharmacological Verification Mechanism of Yeju Jiangya Decoction on Hypertension

Figure 14

The NO pathway involved in this study is that L (+) arginine oxidizes to NO and L-guanidine. NO activates soluble guanylate cyclase (sGC) by retrograde diffusion, enhances the level of cGMP in cells, and cGMP reregulates cGMP-dependent protein kinase (PRKG1) to reduce intracellular Ca²⁺ and induce vasodilation. L-NNA is used to block NO synthesis and contraction of smooth muscle. “×,” inhibit.