Research Article

Lymphocyte and Platelet Counts, as well as Interleukin-6 Levels, Predict Mortality of Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis

Table 4

The baseline characteristics.

StudyYearCountryType of studySampleAgeMaleLymphocyte count (×109/L)Platelet count (×109/L)IL-6 (pg/mL)

Survival
Ruan et al. [a]50 (44–81)53 (65%)1.42 (2.14)222.1 (78.0)6.8 (3.61)
Zhou et al. [b]2020ChinaRetrospective19152 (45–58)81 (59%)1.1 (0.8–1.5)220.0 (168.0–271.0)6.3 (5·0–7.9)
Yang et al. [c]2020ChinaRetrospective5251.9 (12.9)14 (70%)0.74 (0.40)164 (74)
Deng et al. [d]2020ChinaRetrospective22540 (33, 57)51 (44%)1.00 (0.72, 1.27)
Wang et al. [e]2020ChinaRetrospective33968 (64–74)127 (49%)0.97 (0.68–1.37)211 (159–268)10.5 (4.9–18.8)
Du et al. [f]2020ChinaProspective17956.0 ± 13.587 (55.1%)0.8 (0.6–1.1)
Xu et al. [g]2020ChinaRetrospective14556 [43, 66]59 (50.4%)0.93 [0.65, 1.37]14.65 [4.24, 27]
Takahisa et al. [h]2020USARetrospective282062 [49, 73]1128/2014 (56%)0.90 [0.70, 1.30]212.0 [166.0, 267.0]45.8 [23.3, 82.4]
Xu et al. [i]2020ChinaRetrospective23957.5 ± 13.553 (57.6%)0.7 [0.50–0.9]186 [148–232]9.1 [6.2–11.7]

Death
Ruan et al. [a]2020ChinaRetrospective15067 (15–81)49 (72%)0.60 (0.32)173.6 (67.7)11.4 (8.5)
Zhou et al. [b]2020ChinaRetrospective19169 (63–76)38 (70%)0.6 (0.5–0.8)165.5 (107.0–229.0)11.0 (7.5–14.4)
Yang et al. [c]2020ChinaRetrospective5264.6 (11.2)21 (66%)0.62 (0.37)191 (63)
Deng et al. [d]2020ChinaRetrospective22569 (62, 74)73 (67.0)0.63 (0.40, 0.79)
Wang et al. [e]2020ChinaRetrospective33976 (70–83)39 (60%)0.57 (0.39–0.84)172 (103–219)93.8 (35.9–182.3)
Du et al. [f]2020ChinaProspective17970.2 ± 7.710 (47.6)0.7 (0.5–0.8)
Xu et al. [g]2020ChinaRetrospective14573 [68, 77.25]17 (60.7)0.56 [0.32, 0.94]29.8 [14.6, 63.89]
Takahisa et al. [h]2020USARetrospective282076 [65, 85]483/806 (59.9)0.80 [0.50, 1.10]197.0 [146.0, 252.0]152.4 [79.1, 303.8]
Xu et al. [i]2020ChinaRetrospective23965.7 ± 12.290 (61.2%)0.6 [0.4–0.8]160 [110–206]9.1 [7.1–12.9]