Aboriginal Bacterial Flora in the Uricase-Deficient Rat Gut is Not the Main Factor Affecting Serum Uric Acid
Table 1
The top 10 genera in rat stool.
No.
WT
Uox-/-−1
Uox-/-−2∗
Genus
Abundance (%)
Genus
Abundance (%)
Genus
Abundance (%)
1
Cronobacter
29.60
Lactobacillus
16.72
Lactobacillus
24.39
2
Vibrio
24.40
Cronobacter
15.44
Lactobacillus_H
19.91
3
Lactobacillus
7.51
Prevotella
9.13
Lactobacillus_B
19.37
4
Lactobacillus_B
5.08
Vibrio
5.85
Rothia
10.65
5
Salmonella
3.82
Lactobacillus_H
4.55
Cronobacter
4.00
6
Lactobacillus_H
2.68
Kineothrix
4.01
Pseudomonas_E
2.03
7
Eubacterium_R
2.18
Treponema_D
3.52
Vibrio
1.33
8
Chryseobacterium
2.01
Salmonella
3.43
Enterococcus
1.26
9
Duncaniella
1.53
Schwartzia
2.96
Streptococcus
1.11
10
Prevotella
1.35
Saccharimonas
2.93
Saccharimonas
1.04
Total (267)
80.20
Total (275)
68.50
Total (317)
67.55
More than 99% of bacteria in stool were inhibited or killed in the Uox-/-−2 group treated by the combination of antibiotics. WT rats, wild-type rats; Uox-/-−1, normal Uox-/- rats; Uox-/-−2, Uox-/- rats treated with combinatorial antibiotics (ampicillin (90 mg/kg) and ciprofloxacin (150 mg/kg) for 5 days).
